-transparent.png){kind=logo}
Structure-activity relationships of N-substituted ligands for the alpha7 nicotinic acetylcholine receptor. 2010
Kathleen H Mortell, and
Michael R Schrimpf, and
William H Bunnelle, and
David J Anderson, and
Jens Halvard Gronlien, and
Kirsten Thorin Hagene, and
Murali Gopalakrishnan
Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA. kathleen.mortell@abbott.com
A series of alpha7 neuronal nicotinic acetylcholine receptor ligands were designed based on a structural combination of a potent, but non-selective ligand, epibatidine, with a selective lead structure, 2. Three series of compounds in which aryl moieties were attached via a linker to different positions on the core structure were studied. A potent and functionally efficacious analog, (3aR,6aS)-2-(6-phenylpyridazin-3-yl)-5-(pyridin-3-ylmethyl)octahydropyrrolo[3,4-c]pyrrole (3a), was identified.
Related Publications
Kathleen H Mortell, and
Michael R Schrimpf, and
William H Bunnelle, and
David J Anderson, and
Jens Halvard Gronlien, and
Kirsten Thorin Hagene, and
Murali Gopalakrishnan
December 2000,
Journal of molecular biology,
Kathleen H Mortell, and
Michael R Schrimpf, and
William H Bunnelle, and
David J Anderson, and
Jens Halvard Gronlien, and
Kirsten Thorin Hagene, and
Murali Gopalakrishnan
January 2006,
Current medicinal chemistry,
Kathleen H Mortell, and
Michael R Schrimpf, and
William H Bunnelle, and
David J Anderson, and
Jens Halvard Gronlien, and
Kirsten Thorin Hagene, and
Murali Gopalakrishnan
December 1996,
Bioorganic & medicinal chemistry,
Kathleen H Mortell, and
Michael R Schrimpf, and
William H Bunnelle, and
David J Anderson, and
Jens Halvard Gronlien, and
Kirsten Thorin Hagene, and
Murali Gopalakrishnan
April 2007,
Bioorganic & medicinal chemistry letters,
Kathleen H Mortell, and
Michael R Schrimpf, and
William H Bunnelle, and
David J Anderson, and
Jens Halvard Gronlien, and
Kirsten Thorin Hagene, and
Murali Gopalakrishnan
January 2007,
International review of neurobiology,
Kathleen H Mortell, and
Michael R Schrimpf, and
William H Bunnelle, and
David J Anderson, and
Jens Halvard Gronlien, and
Kirsten Thorin Hagene, and
Murali Gopalakrishnan
December 2006,
Journal of medicinal chemistry,
Kathleen H Mortell, and
Michael R Schrimpf, and
William H Bunnelle, and
David J Anderson, and
Jens Halvard Gronlien, and
Kirsten Thorin Hagene, and
Murali Gopalakrishnan
June 2007,
Biochemistry,
Kathleen H Mortell, and
Michael R Schrimpf, and
William H Bunnelle, and
David J Anderson, and
Jens Halvard Gronlien, and
Kirsten Thorin Hagene, and
Murali Gopalakrishnan
November 1998,
Neuroscience letters,
Kathleen H Mortell, and
Michael R Schrimpf, and
William H Bunnelle, and
David J Anderson, and
Jens Halvard Gronlien, and
Kirsten Thorin Hagene, and
Murali Gopalakrishnan
February 2008,
Journal of medicinal chemistry,
Kathleen H Mortell, and
Michael R Schrimpf, and
William H Bunnelle, and
David J Anderson, and
Jens Halvard Gronlien, and
Kirsten Thorin Hagene, and
Murali Gopalakrishnan
August 1999,
Molecular neurobiology,
