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Gefitinib trial in a fanconi's anemia patient with multiple squamous cell carcinomas and hepatocellular carcinoma. 2005
Hae Sun Jung, and
Gun-Woo Byun, and
Kyoung-Eun Lee, and
Yeung Chul Mun, and
Seung Hyun Nam, and
Jung Mi Kwon, and
Shi Nae Lee, and
Seock-Ah Im, and
Chu-Myong Seong, and
Soon Nam Lee
Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea.
FA (Fanconi's Anemia) is an autosomal recessive disorder that is characterized by pancytopenia with bone marrow hypoplasia, diverse congenital abnormalities and an increased predisposition towards malignancy. The mainstay of the treatment for these cancers has been surgery, because of the hypersensitive reactions of FA patients to DNA cross- linking agents or radiation. Therefore, there has been no effective therapy for advanced squamous cell carcinoma. We report here on a patient suffering from advanced multiple squamous cell carcinoma and hepatocellular carcinoma along with an FA, and this patient was treated with gefitinib.
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