In vitro adhesion measurements between skin and micropatterned poly(dimethylsiloxane) surfaces. 2009

E J De Souza, and M Kamperman, and G Castellanos, and E Kroner, and V Armbruester, and M S Romann, and B Schick, and E Arzt
INM, Leibniz-Institut für Neue Materialien gGmbH, Campus D2, 2D-66123 Saarbrücken, Germany. emersonjose.desouza@inm-gmbh.de

Micropatterned adhesive surfaces may have potential in reconstructive surgery. The adhesion performance of mice ear skin to micropatterned poly(dimethylsiloxane) (PDMS) was investigated, under in vitro conditions, and compared to flat substrates. No significant difference in separation force F was observed between flat substrates and micropatterned surfaces with pillar arrays. However, the energy necessary for separation of the substrate from the skin was sensitive to the topography. Furthermore, our results show that the force-displacement curves depended on the wetness of the skin: Highest force values were obtained for fresh skin while the forces decreased as the skin dried out. The results are encouraging for further studies on the potential of patterned PDMS in biomedical applications.

UI MeSH Term Description Entries
D008422 Materials Testing The testing of materials and devices, especially those used for PROSTHESES AND IMPLANTS; SUTURES; TISSUE ADHESIVES; etc., for hardness, strength, durability, safety, efficacy, and biocompatibility. Biocompatibility Testing,Biocompatible Materials Testing,Hemocompatibility Testing,Testing, Biocompatible Materials,Testing, Hemocompatible Materials,Hemocompatibility Testings,Hemocompatible Materials Testing,Materials Testing, Biocompatible,Materials Testing, Hemocompatible,Testing, Biocompatibility,Testing, Hemocompatibility,Testing, Materials,Testings, Biocompatibility
D009757 Nylons Polymers where the main polymer chain comprises recurring amide groups. These compounds are generally formed from combinations of diamines, diacids, and amino acids and yield fibers, sheeting, or extruded forms used in textiles, gels, filters, sutures, contact lenses, and other biomaterials. Polyamides,Dermalon,Ethilon,Nylon,Polyamide,Supramid,Dermalons,Ethilons,Supramids
D011474 Prosthesis Design The plan and delineation of prostheses in general or a specific prosthesis. Design, Prosthesis,Designs, Prosthesis,Prosthesis Designs
D004129 Dimethylpolysiloxanes Silicone polymers which consist of silicon atoms substituted with methyl groups and linked by oxygen atoms. They comprise a series of biocompatible materials used as liquids, gels or solids; as film for artificial membranes, gels for implants, and liquids for drug vehicles; and as antifoaming agents. Dimethylsiloxanes,Polydimethylsiloxanes,Dimethylpolysiloxane,Dimethylsiloxane
D000268 Adhesiveness A property of the surface of an object that makes it stick to another surface. Adhesivenesses
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001672 Biocompatible Materials Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function. Biomaterials,Bioartificial Materials,Hemocompatible Materials,Bioartificial Material,Biocompatible Material,Biomaterial,Hemocompatible Material,Material, Bioartificial,Material, Biocompatible,Material, Hemocompatible
D012879 Skin Physiological Phenomena The functions of the skin in the human and animal body. It includes the pigmentation of the skin. Skin Physiological Processes,Skin Physiology,Physiology, Skin,Skin Physiological Concepts,Skin Physiological Phenomenon,Skin Physiological Process,Concept, Skin Physiological,Concepts, Skin Physiological,Phenomena, Skin Physiological,Phenomenas, Skin Physiological,Phenomenon, Skin Physiological,Phenomenons, Skin Physiological,Physiological Concept, Skin,Physiological Concepts, Skin,Physiological Phenomena, Skin,Physiological Phenomenas, Skin,Physiological Phenomenon, Skin,Physiological Phenomenons, Skin,Process, Skin Physiological,Processes, Skin Physiological,Skin Physiological Concept,Skin Physiological Phenomenas,Skin Physiological Phenomenons
D013499 Surface Properties Characteristics or attributes of the outer boundaries of objects, including molecules. Properties, Surface,Property, Surface,Surface Property
D017768 Skin, Artificial Synthetic material used for the treatment of burns and other conditions involving large-scale loss of skin. It often consists of an outer (epidermal) layer of silicone and an inner (dermal) layer of collagen and chondroitin 6-sulfate. The dermal layer elicits new growth and vascular invasion and the outer layer is later removed and replaced by a graft. Artificial Skin,Skin Substitutes,Artificial Skins,Skin Substitute,Skins, Artificial,Substitute, Skin,Substitutes, Skin

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