OBJECTIVE In this study, we have tried to model the effects of intra-aortic balloon pump (IABP) on myocardial infarction (MI) using the standardized data of MI in sheep which was obtained by ligation of the left anterior descending coronary artery. METHODS Mathematical model of whole cardiovascular system was presented in accordance to the arterial tree. The lumped parameter model was primarily obtained for a rigid vessel regarding the vessel diameter. In this study, the proper lumped model of every vessel was obtained by incorporating the rigid vessel lumped model into the capacitance as a compliance of the vessel. Intra-aortic balloon pump was modeled with the hemodynamic parameters of the aorta. It was assumed that balloon pump inflates at the beginning of the diastole and deflates near the beginning of the next systole. RESULTS During balloon pumping, the vessel diameter variation function counter pulsates sinusoidally with the same period of the cardiac cycle. End systolic pressure and end diastolic pressure decreases along with hemodynamic flow optimized through systemic arteries due to balloon pumping in diastole. It has been shown that the blood flow in subclavian artery increases as well. Moreover, the cardiac work keeps low, which prone to lower oxygen consumption. The results of modeling are in good agreement with IABP documentation. CONCLUSIONS The presented model is a useful tool for studying of the cardiovascular system pathology and the presented modeling data are in good agreement with the experimental ones.