-transparent.png){kind=logo}
In most instances of acute poststreptococcal glomerulonephritis (APSGN), activation of the complement system occurs, as reflected by decreased levels of the complement proteins C3, C5, and properdin (P). Recent studies implicate terminal complement complexes (TCC) in the pathogenesis of glomerular injury. The fluid phase TCC, SC5b-9, reflects the formation of membrane-bound C5b-9 and has been used as a clinical marker in various diseases. Plasma concentrations of SC5b-9 were measured with an enzyme immunoassay using a monoclonal antibody to a neoantigen expressed on the SC5b-9 complex in 13 children who presented with clinical and pathologic features of APSGN. SC5b-9 was significantly elevated in all plasmas obtained within 30 days after onset of clinical glomerulonephritis. Concentrations of SC5b-9 in acute plasmas were significantly higher than those of paired convalescent samples. For individual patients, as SC5b-9 concentration returned to normal there was a coincident decrease in serum creatinine concentration and urinary protein excretion, signifying clinical improvement in glomerulonephritis. Thus, TCC generation commonly occurs in the early stages of APSGN and may be of importance in the pathogenesis of the condition.
D G Matsell, and
S Roy, and
J D Tamerius, and
P R Morrow, and
W P Kolb, and
R J Wyatt
December 1994,
Pediatric nephrology (Berlin, Germany),
D G Matsell, and
S Roy, and
J D Tamerius, and
P R Morrow, and
W P Kolb, and
R J Wyatt
January 1979,
International archives of allergy and applied immunology,
D G Matsell, and
S Roy, and
J D Tamerius, and
P R Morrow, and
W P Kolb, and
R J Wyatt
January 1991,
Medicinski arhiv,
D G Matsell, and
S Roy, and
J D Tamerius, and
P R Morrow, and
W P Kolb, and
R J Wyatt
May 1977,
British medical journal,
D G Matsell, and
S Roy, and
J D Tamerius, and
P R Morrow, and
W P Kolb, and
R J Wyatt
May 1980,
Israel journal of medical sciences,
D G Matsell, and
S Roy, and
J D Tamerius, and
P R Morrow, and
W P Kolb, and
R J Wyatt
May 1982,
Nursing,
D G Matsell, and
S Roy, and
J D Tamerius, and
P R Morrow, and
W P Kolb, and
R J Wyatt
July 1995,
Pediatrics in review,
D G Matsell, and
S Roy, and
J D Tamerius, and
P R Morrow, and
W P Kolb, and
R J Wyatt
November 1976,
Pediatric clinics of North America,
D G Matsell, and
S Roy, and
J D Tamerius, and
P R Morrow, and
W P Kolb, and
R J Wyatt
July 1985,
Hospital practice (Office ed.),
D G Matsell, and
S Roy, and
J D Tamerius, and
P R Morrow, and
W P Kolb, and
R J Wyatt
January 1980,
Clinical nephrology,
