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[A case of HIV coinfected with hepatitis B virus treated by entecavir]. 2009
Akihiro Yamada, and
Akahito Sako, and
So Nishimura, and
Ryo Nakashima, and
Toshiko Ogami, and
Keiichi Fujiya, and
Naonori Tsuda, and
Naoki Asayama, and
Tomoyuki Yada, and
Kiyokazu Shirai, and
Naoki Akazawa, and
Toshiyuki Sakurai, and
Yuzo Yago, and
Naoyoshi Nagata, and
Takao Oshima, and
Chizu Yokoi, and
Keita Sasajima, and
Masao Kobayakawa, and
Junichi Akiyama, and
Masatoshi Imamura, and
Mikio Yanase, and
Naomi Uemura, and
Naohiko Masaki
Division of Gastroenterology, Toyama Hospital, International Medical Center of Japan, Japan. akihiyamada-gi@umin.ac.jp
A 45-year-old male active homosexual was given a diagnosis of HIV-1 and acute hepatitis B in August 2007. Since his liver function became rapidly impaired, anti-HBV therapy with oral administration of entecavir (ETV) was started, and resulted in a favorable outcome. However, serum concentration of HIV-RNA decreased by log 1.26 within 60 days, which strongly suggested the inhibition of HIV proliferation by ETV. To prevent the appearance of mutated HIV, novel therapeutic strategies should be established in HIV/HBV-coinfected patients.
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