Testicular fine needle aspiration cytology in azoospermic males. 2009

R C Adhikari
Department of Pathology, Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal. rcadhikari@hotmail.com

One hundred one azoospermic males were subjected to fine needle aspiration cytology (FNAC) of the testis and 11 of them underwent testicular biopsy as well. In 99 cases, the aspiration was adequate for classifying into different categories, which are as follows: Sertoli cell only syndrome (46), normal spermatogenesis (27), hypospermatogenesis (10), tubular/peritubular sclerosis (10) and maturation arrest (6). The percentage population of Sertoli cells and spermatogenetic cells and cell indices including spermatic index, Sertoli cell index and sperm-Sertoli cell index were calculated. In normal spermatogenesis, fine needle aspiration (FNA) smears showed upto 40.0% Sertoli cells and spermatozoa were the predominant spermatogenetic cell type. In Sertoli cell only syndrome, there were sheets of Sertoli cells that constituted 88.0-100.0%. Progressively increasing values of the Sertoli cell index and progressively decreasing values of the sperm-Sertoli index were seen in normal spermatogenesis, maturation arrest, hypospermatogenesis, tubular/peritubular sclerosis and Sertoli cell only syndrome. In this study, complete agreement between testicular FNAC and histology was noted. Pecentage cell counts and cell indices in testicular FNA and 100.0% cyto - histo correlation make the FNAC preferable to biopsy in assessing azoospermic males.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D012189 Retrospective Studies Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons. Retrospective Study,Studies, Retrospective,Study, Retrospective
D012708 Sertoli Cells Supporting cells projecting inward from the basement membrane of SEMINIFEROUS TUBULES. They surround and nourish the developing male germ cells and secrete the ANDROGEN-BINDING PROTEIN and hormones such as ANTI-MULLERIAN HORMONE. The tight junctions of Sertoli cells with the SPERMATOGONIA and SPERMATOCYTES provide a BLOOD-TESTIS BARRIER. Sertoli Cell,Cell, Sertoli,Cells, Sertoli
D013737 Testis The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS. Testicles,Testes,Testicle
D044963 Biopsy, Fine-Needle Using fine needles (finer than 22-gauge) to remove tissue or fluid specimens from the living body for examination in the pathology laboratory and for disease diagnosis. Aspiration Biopsy, Fine-Needle,Fine Needle Biopsy,Fine-Needle Aspiration,Aspiration Biopsies, Fine-Needle,Aspiration Biopsy, Fine Needle,Aspiration, Fine-Needle,Aspirations, Fine-Needle,Biopsies, Fine Needle,Biopsies, Fine-Needle,Biopsies, Fine-Needle Aspiration,Biopsy, Fine Needle,Biopsy, Fine-Needle Aspiration,Fine Needle Aspiration,Fine Needle Biopsies,Fine-Needle Aspiration Biopsies,Fine-Needle Aspiration Biopsy,Fine-Needle Aspirations,Fine-Needle Biopsies,Fine-Needle Biopsy,Needle Biopsies, Fine,Needle Biopsy, Fine
D053713 Azoospermia A condition of having no sperm present in the ejaculate (SEMEN).

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