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Aberrant crypts were identified for the first time in whole-mount preparations of normal-appearing human colonic mucosa after staining with methylene blue. The foci of aberrant crypts varied from single altered glands to plaques of greater than 30 crypts. The mean proportion of colonic mucosa altered and the number of foci with aberrant crypts per cm2 of colonic mucosa were (a) higher in patients with colon cancer than in patients without colon cancer or predisposing conditions and (b) highest in our single case of Gardner's syndrome. Aberrant crypts are postulated to be the earliest identifiable potential precursors of colon cancer. Analysis of aberrant crypts may facilitate the study of the early pathological and molecular changes that precede colon cancer.
T P Pretlow, and
B J Barrow, and
W S Ashton, and
M A O'Riordan, and
T G Pretlow, and
J A Jurcisek, and
T A Stellato
January 1992,
Journal of cellular biochemistry. Supplement,
T P Pretlow, and
B J Barrow, and
W S Ashton, and
M A O'Riordan, and
T G Pretlow, and
J A Jurcisek, and
T A Stellato
January 1994,
Journal of cellular biochemistry. Supplement,
T P Pretlow, and
B J Barrow, and
W S Ashton, and
M A O'Riordan, and
T G Pretlow, and
J A Jurcisek, and
T A Stellato
August 2008,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
T P Pretlow, and
B J Barrow, and
W S Ashton, and
M A O'Riordan, and
T G Pretlow, and
J A Jurcisek, and
T A Stellato
November 1988,
Cancer research,
T P Pretlow, and
B J Barrow, and
W S Ashton, and
M A O'Riordan, and
T G Pretlow, and
J A Jurcisek, and
T A Stellato
July 1997,
Carcinogenesis,
T P Pretlow, and
B J Barrow, and
W S Ashton, and
M A O'Riordan, and
T G Pretlow, and
J A Jurcisek, and
T A Stellato
May 2009,
Carcinogenesis,
T P Pretlow, and
B J Barrow, and
W S Ashton, and
M A O'Riordan, and
T G Pretlow, and
J A Jurcisek, and
T A Stellato
June 1996,
Carcinogenesis,
T P Pretlow, and
B J Barrow, and
W S Ashton, and
M A O'Riordan, and
T G Pretlow, and
J A Jurcisek, and
T A Stellato
December 1994,
Gastroenterology,
T P Pretlow, and
B J Barrow, and
W S Ashton, and
M A O'Riordan, and
T G Pretlow, and
J A Jurcisek, and
T A Stellato
November 2006,
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology,
T P Pretlow, and
B J Barrow, and
W S Ashton, and
M A O'Riordan, and
T G Pretlow, and
J A Jurcisek, and
T A Stellato
November 1991,
Carcinogenesis,
