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Thalidomide selectively inhibits the production of human monocyte tumor necrosis factor alpha (TNF-alpha) when these cells are triggered with lipopolysaccharide and other agonists in culture. 40% inhibition occurs at the clinically achievable dose of the drug of 1 micrograms/ml. In contrast, the amount of total protein and individual proteins labeled with [35S]methionine and expressed on SDS-PAGE are not influenced. The amounts of interleukin 1 beta (IL-1 beta), IL-6, and granulocyte/macrophage colony-stimulating factor produced by monocytes remain unaltered. The selectivity of this drug may be useful in determining the role of TNF-alpha in vivo and modulating its toxic effects in a clinical setting.
E P Sampaio, and
E N Sarno, and
R Galilly, and
Z A Cohn, and
G Kaplan
October 1995,
The Journal of infectious diseases,
E P Sampaio, and
E N Sarno, and
R Galilly, and
Z A Cohn, and
G Kaplan
April 1992,
Journal of immunology (Baltimore, Md. : 1950),
E P Sampaio, and
E N Sarno, and
R Galilly, and
Z A Cohn, and
G Kaplan
October 1992,
The Annals of otology, rhinology & laryngology. Supplement,
E P Sampaio, and
E N Sarno, and
R Galilly, and
Z A Cohn, and
G Kaplan
November 2003,
The Journal of investigative dermatology,
E P Sampaio, and
E N Sarno, and
R Galilly, and
Z A Cohn, and
G Kaplan
December 2009,
Journal of periodontal research,
E P Sampaio, and
E N Sarno, and
R Galilly, and
Z A Cohn, and
G Kaplan
October 1996,
American journal of respiratory cell and molecular biology,
E P Sampaio, and
E N Sarno, and
R Galilly, and
Z A Cohn, and
G Kaplan
August 1999,
Molecular cell biology research communications : MCBRC,
E P Sampaio, and
E N Sarno, and
R Galilly, and
Z A Cohn, and
G Kaplan
July 1999,
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research,
E P Sampaio, and
E N Sarno, and
R Galilly, and
Z A Cohn, and
G Kaplan
December 1991,
Lipids,
E P Sampaio, and
E N Sarno, and
R Galilly, and
Z A Cohn, and
G Kaplan
June 1992,
European journal of immunology,
