BIOMAT Database Logo BIOMAT Database Logo

The antiemetic activity of high-dose metoclopramide and high-dose alizapride in combination with lorazepam in patients receiving cancer chemotherapy. A prospective, randomized, double-blind study. 1991

A Molino, and L Guglielmo, and M E Azzolini, and P Biondani, and M C Capelli, and A Grandinetti, and C Griso, and G Martinelli, and N Martini, and R Zanotti
Cattedra di Oncologia Medica, Università di Verona, Italia.

The antiemetic efficacy of metoclopramide and lorazepam (MTC + L) versus alizapride and lorazepam (ALZ + L) was compared in 100 patients receiving chemotherapy, in a prospective randomized double-blind study. In highly emetogenic (HE) regimen (including platinum) patients received MTC 1 mg/kg or ALZ 3 mg/kg x 4 doses, and lorazepam 2.5 mg 30 min before therapy. In moderately emetogenic (ME) regimen patients received MTC 0.5 mg/kg or ALZ 1.5 mg kg x 3 doses, and lorazepam 2.5 mg 30 min before therapy. In both HE and ME regimen groups there was no statistically significant difference between MTC + L and ALZ + L treatments as regards the number of vomiting episodes, the duration of emesis and nausea, the intensity of nausea and side effects, but a statistically significant difference between treatments was found in the HE group where MTC-L was superior to ALZ + L in obtaining complete protection from vomiting (37 vs 11%, p = 0.05). No significant difference in side effects was observed.

UI MeSH Term Description Entries
D008140 Lorazepam A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent. Apo-Lorazepam,Ativan,Donix,Duralozam,Durazolam,Idalprem,Laubeel,Lorazep Von Ct,Lorazepam Medical,Lorazepam-Neuraxpharm,Lorazepam-Ratiopharm,Novo-Lorazem,Nu-Loraz,Orfidal Wyeth,Sedicepan,Sinestron,Somagerol,Temesta,Tolid,Témesta,WY-4036,Apo Lorazepam,Lorazepam Neuraxpharm,Lorazepam Ratiopharm,Medical, Lorazepam,Novo Lorazem,Nu Loraz,Von Ct, Lorazep,WY 4036,WY4036,Wyeth, Orfidal
D008297 Male Males
D008787 Metoclopramide A dopamine D2 antagonist that is used as an antiemetic. 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide,Cerucal,Maxolon,Metaclopramide,Metoclopramide Dihydrochloride,Metoclopramide Hydrochloride,Metoclopramide Monohydrochloride,Metoclopramide Monohydrochloride, Monohydrate,Primperan,Reglan,Rimetin,Dihydrochloride, Metoclopramide,Hydrochloride, Metoclopramide,Monohydrochloride, Metoclopramide
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D011759 Pyrrolidines Compounds also known as tetrahydropyridines with general molecular formula (CH2)4NH. Tetrahydropyridine,Tetrahydropyridines
D004311 Double-Blind Method A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment. Double-Masked Study,Double-Blind Study,Double-Masked Method,Double Blind Method,Double Blind Study,Double Masked Method,Double Masked Study,Double-Blind Methods,Double-Blind Studies,Double-Masked Methods,Double-Masked Studies,Method, Double-Blind,Method, Double-Masked,Methods, Double-Blind,Methods, Double-Masked,Studies, Double-Blind,Studies, Double-Masked,Study, Double-Blind,Study, Double-Masked
D004359 Drug Therapy, Combination Therapy with two or more separate preparations given for a combined effect. Combination Chemotherapy,Polychemotherapy,Chemotherapy, Combination,Combination Drug Therapy,Drug Polytherapy,Therapy, Combination Drug,Chemotherapies, Combination,Combination Chemotherapies,Combination Drug Therapies,Drug Polytherapies,Drug Therapies, Combination,Polychemotherapies,Polytherapies, Drug,Polytherapy, Drug,Therapies, Combination Drug
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

A Molino, and L Guglielmo, and M E Azzolini, and P Biondani, and M C Capelli, and A Grandinetti, and C Griso, and G Martinelli, and N Martini, and R Zanotti
The antiemetic activity of high-dose alizapride and high-dose metoclopramide in patients receiving cancer chemotherapy: a prospective, randomized, double-blind trial.
June 1986, Clinical pharmacology and therapeutics,
A Molino, and L Guglielmo, and M E Azzolini, and P Biondani, and M C Capelli, and A Grandinetti, and C Griso, and G Martinelli, and N Martini, and R Zanotti
A prospective randomized double-blind crossover study comparing the antiemetic activity of alizapride and metoclopramide in patients receiving cisplatin chemotherapy.
January 1988, Cancer investigation,
A Molino, and L Guglielmo, and M E Azzolini, and P Biondani, and M C Capelli, and A Grandinetti, and C Griso, and G Martinelli, and N Martini, and R Zanotti
Antiemetic efficacy of high-dose dexamethasone: randomized, double-blind, crossover study with high-dose metoclopramide in patients receiving cancer chemotherapy.
March 1986, European journal of cancer & clinical oncology,
A Molino, and L Guglielmo, and M E Azzolini, and P Biondani, and M C Capelli, and A Grandinetti, and C Griso, and G Martinelli, and N Martini, and R Zanotti
A randomized, double-blind comparison of the antiemetic effect of metoclopramide and lorazepam with or without dexamethasone in patients receiving high-dose cisplatin.
August 1990, Cancer,
A Molino, and L Guglielmo, and M E Azzolini, and P Biondani, and M C Capelli, and A Grandinetti, and C Griso, and G Martinelli, and N Martini, and R Zanotti
Randomized, double-blind, cross-over study comparing prochlorperazine and lorazepam with high-dose metoclopramide and lorazepam for the control of emesis in patients receiving cytotoxic chemotherapy.
November 1987, Cancer treatment reports,
A Molino, and L Guglielmo, and M E Azzolini, and P Biondani, and M C Capelli, and A Grandinetti, and C Griso, and G Martinelli, and N Martini, and R Zanotti
Antiemetic activity of metoclopramide versus alizapride during cancer chemotherapy.
December 1985, Tumori,
A Molino, and L Guglielmo, and M E Azzolini, and P Biondani, and M C Capelli, and A Grandinetti, and C Griso, and G Martinelli, and N Martini, and R Zanotti
Lorazepam: a randomized, double-blind, crossover study of a new antiemetic in patients receiving cytotoxic chemotherapy and prochlorperazine.
June 1984, Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
A Molino, and L Guglielmo, and M E Azzolini, and P Biondani, and M C Capelli, and A Grandinetti, and C Griso, and G Martinelli, and N Martini, and R Zanotti
Antiemetic efficacy of high-dose dexamethasone: randomized, double-blind, crossover study with a combination of dexamethasone, metoclopramide and diphenhydramine.
March 1988, British journal of cancer,
A Molino, and L Guglielmo, and M E Azzolini, and P Biondani, and M C Capelli, and A Grandinetti, and C Griso, and G Martinelli, and N Martini, and R Zanotti
Antiemetics in children receiving cancer chemotherapy: a double-blind prospective randomized study comparing metoclopramide with chlorpromazine.
July 1986, Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
A Molino, and L Guglielmo, and M E Azzolini, and P Biondani, and M C Capelli, and A Grandinetti, and C Griso, and G Martinelli, and N Martini, and R Zanotti
High-dose metoclopramide as an antiemetic in patients receiving cis-platinum-based combination chemotherapy.
May 1985, Gynecologic oncology,
Copied contents to your clipboard!