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3,3-Dimethyl-1-phenyltriazene (DMPT) is a methylating agent which is carcinogenic, teratogenic and mutagenic which, in the rat, provides a reproducible animal model with which to study the basis of chemically-induced micrognathism. The basis of teratogenic organotropism of DMPT and other methylating teratogens is unknown. The present study was undertaken to determine if limited chemical distribution within the embryo was responsible for the organotropism of DMPT. Whole-embryo autoradiographs and liquid scintillation analysis indicated that although DMPT may have some limitations of chemical distribution within the embryo, these limitations are not sufficient to explain its teratogenic organotropism.
A A Frank, and
E A Kazacos, and
D J Thompson
August 1976,
Chemico-biological interactions,
A A Frank, and
E A Kazacos, and
D J Thompson
August 1978,
Acta neuropathologica,
A A Frank, and
E A Kazacos, and
D J Thompson
March 1997,
Kokubyo Gakkai zasshi. The Journal of the Stomatological Society, Japan,
A A Frank, and
E A Kazacos, and
D J Thompson
July 1985,
Carcinogenesis,
A A Frank, and
E A Kazacos, and
D J Thompson
November 1957,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
A A Frank, and
E A Kazacos, and
D J Thompson
April 1979,
Journal of cancer research and clinical oncology,
A A Frank, and
E A Kazacos, and
D J Thompson
January 1992,
Toxicologic pathology,
A A Frank, and
E A Kazacos, and
D J Thompson
May 1984,
Cancer letters,
A A Frank, and
E A Kazacos, and
D J Thompson
July 1976,
Cancer research,
A A Frank, and
E A Kazacos, and
D J Thompson
June 1973,
Mutation research,
