-transparent.png){kind=logo}
CMK is a human cell line derived from a megakaryoblastic leukaemia. It has characteristics of the megakaryocytic lineage, such as the presence of platelet peroxidase, membrane glycoproteins (GP)Ib and GPIIb/IIIa, alpha-granules, and demarcation membranes. The cell line proliferates autonomously in serum-containing medium. Here we report that the cell line expresses the gene for IL-6 and releases small quantities of the cytokine into the medium. Addition of exogenous IL-6 to cultures seeded into medium was found to promote growth of the cells. Conversely, addition of a neutralizing anti-IL-6 antibody inhibited cell growth. These data support the notion that autocrine IL-6 is one of the factors accounting for autonomous growth of the cell line.
A Fuse, and
H Kakuda, and
Y Shima, and
J Van Damme, and
A Billiau, and
T Sato
February 1997,
Leukemia research,
A Fuse, and
H Kakuda, and
Y Shima, and
J Van Damme, and
A Billiau, and
T Sato
July 1989,
Blood,
A Fuse, and
H Kakuda, and
Y Shima, and
J Van Damme, and
A Billiau, and
T Sato
January 1994,
Journal of gastroenterology and hepatology,
A Fuse, and
H Kakuda, and
Y Shima, and
J Van Damme, and
A Billiau, and
T Sato
February 1997,
Zhonghua bing li xue za zhi = Chinese journal of pathology,
A Fuse, and
H Kakuda, and
Y Shima, and
J Van Damme, and
A Billiau, and
T Sato
November 1998,
Journal of neurochemistry,
A Fuse, and
H Kakuda, and
Y Shima, and
J Van Damme, and
A Billiau, and
T Sato
January 1997,
Zhonghua zhong liu za zhi [Chinese journal of oncology],
A Fuse, and
H Kakuda, and
Y Shima, and
J Van Damme, and
A Billiau, and
T Sato
October 1988,
Journal of cellular physiology,
A Fuse, and
H Kakuda, and
Y Shima, and
J Van Damme, and
A Billiau, and
T Sato
December 1994,
Leukemia,
A Fuse, and
H Kakuda, and
Y Shima, and
J Van Damme, and
A Billiau, and
T Sato
October 1991,
Experimental hematology,
A Fuse, and
H Kakuda, and
Y Shima, and
J Van Damme, and
A Billiau, and
T Sato
May 1990,
Biochemical and biophysical research communications,
