-transparent.png){kind=logo}
The role of 2-aminofluorene and its N-glucuronide and the O-glucuronide of N-hydroxy-2-acetylaminofluorene in the bladder carcinogenesis by 2-aminofluorene were investigated. These compounds were injected into heterotopically transplanted bladders of male rats at a weekly dose of 1 mumol for 20 weeks. The experiment was terminated at the end of 50 weeks. The results showed that none of these compounds were carcinogenic in the heterotopically transplanted bladder. The O-glucuronide was not carcinogenic even when it was administered in a phosphate saline (pH 8.0), that favors the activation of this compound. The N-glucuronide of N-hydroxy-2-aminofluorene, a positive control, produced urothelial tumors. These results are consistent with the hypothesis that the N-glucuronides of hydroxylamines, but not the O-glucuronides of hydroxamic acids, are responsible for bladder carcinogenesis by arylamines.
C Y Wang, and
K Imaida, and
K Zukowski, and
M S Lee
May 1967,
Cancer research,
C Y Wang, and
K Imaida, and
K Zukowski, and
M S Lee
April 1969,
Cancer research,
C Y Wang, and
K Imaida, and
K Zukowski, and
M S Lee
November 1982,
Cancer research,
C Y Wang, and
K Imaida, and
K Zukowski, and
M S Lee
March 1965,
The Journal of biological chemistry,
C Y Wang, and
K Imaida, and
K Zukowski, and
M S Lee
November 1971,
Cancer research,
C Y Wang, and
K Imaida, and
K Zukowski, and
M S Lee
October 1980,
Cancer research,
C Y Wang, and
K Imaida, and
K Zukowski, and
M S Lee
May 1976,
Cancer letters,
C Y Wang, and
K Imaida, and
K Zukowski, and
M S Lee
January 1988,
Mutation research,
C Y Wang, and
K Imaida, and
K Zukowski, and
M S Lee
September 1982,
Proceedings of the National Academy of Sciences of the United States of America,
C Y Wang, and
K Imaida, and
K Zukowski, and
M S Lee
March 1987,
Carcinogenesis,
