BIOMAT Database Logo BIOMAT Database Logo

The cardiovascular effects of normobaric hyperoxia in patients with heart rate fixed by permanent pacemaker. 2010

K J Anderson, and J M Harten, and M G Booth, and C Berry, and A McConnachie, and A C Rankin, and J Kinsella
Department of Anaesthesia, University of Glasgow, Glasgow, UK. keithanderson@doctors.net.uk

To investigate whether the established reductions in heart rate and cardiac output with hyperoxia in humans are primary effects or secondary to increases in systemic vascular resistance, we paced the hearts of nine patients with permanent pacemakers at a fixed rate when breathing either medical air (inspired O(2) fraction 0.21) or oxygen (inspired O(2) fraction 0.80) in a randomised, double-blind fashion. A thoracic bio-impedance machine was used to measure heart rate, stroke volume and blood pressure and calculate cardiac index and systemic vascular resistance index. Oxygen caused no change in cardiac index (p = 0.18), stroke index (p = 0.44) or blood pressure (p = 0.52) but caused a small (5.5%) increase in systemic vascular resistance index (p = 0.03). This suggests that hyperoxia has no direct myocardial depressant effects, but that the changes in cardiac output reported in previous studies are secondary to changes in systemic vascular resistance.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010100 Oxygen An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. Dioxygen,Oxygen-16,Oxygen 16
D010102 Oxygen Inhalation Therapy Inhalation of oxygen aimed at restoring toward normal any pathophysiologic alterations of gas exchange in the cardiopulmonary system, as by the use of a respirator, nasal catheter, tent, chamber, or mask. (From Dorland, 27th ed & Stedman, 25th ed) Inhalation Therapy, Oxygen,Therapy, Oxygen Inhalation,Inhalation Therapies, Oxygen,Oxygen Inhalation Therapies,Therapies, Oxygen Inhalation
D010138 Pacemaker, Artificial A device designed to stimulate, by electric impulses, contraction of the heart muscles. It may be temporary (external) or permanent (internal or internal-external). Cardiac Pacemaker, Artificial,Artificial Cardiac Pacemaker,Artificial Cardiac Pacemakers,Artificial Pacemaker,Artificial Pacemakers,Cardiac Pacemakers, Artificial,Pacemaker, Artificial Cardiac,Pacemakers, Artificial,Pacemakers, Artificial Cardiac
D002302 Cardiac Output The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat). Cardiac Outputs,Output, Cardiac,Outputs, Cardiac
D004311 Double-Blind Method A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment. Double-Masked Study,Double-Blind Study,Double-Masked Method,Double Blind Method,Double Blind Study,Double Masked Method,Double Masked Study,Double-Blind Methods,Double-Blind Studies,Double-Masked Methods,Double-Masked Studies,Method, Double-Blind,Method, Double-Masked,Methods, Double-Blind,Methods, Double-Masked,Studies, Double-Blind,Studies, Double-Masked,Study, Double-Blind,Study, Double-Masked
D005260 Female Females
D006339 Heart Rate The number of times the HEART VENTRICLES contract per unit of time, usually per minute. Cardiac Rate,Chronotropism, Cardiac,Heart Rate Control,Heartbeat,Pulse Rate,Cardiac Chronotropy,Cardiac Chronotropism,Cardiac Rates,Chronotropy, Cardiac,Control, Heart Rate,Heart Rates,Heartbeats,Pulse Rates,Rate Control, Heart,Rate, Cardiac,Rate, Heart,Rate, Pulse
D006439 Hemodynamics The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM. Hemodynamic

Related Publications

K J Anderson, and J M Harten, and M G Booth, and C Berry, and A McConnachie, and A C Rankin, and J Kinsella
Cardiovascular response to exercise in pacemaker implanted patients with fixed heart rate.
November 1989, Japanese heart journal,
K J Anderson, and J M Harten, and M G Booth, and C Berry, and A McConnachie, and A C Rankin, and J Kinsella
Control of heart rate by permanent intravenously implanted pacemaker.
November 1967, Journal of the American Geriatrics Society,
K J Anderson, and J M Harten, and M G Booth, and C Berry, and A McConnachie, and A C Rankin, and J Kinsella
Heart rate variability in healthy volunteers during normobaric and hyperbaric hyperoxia.
September 1999, Acta physiologica Scandinavica,
K J Anderson, and J M Harten, and M G Booth, and C Berry, and A McConnachie, and A C Rankin, and J Kinsella
[Physical work capacity in pacemaker implanted patients with fixed heart rate during exercise].
January 1983, Kokyu to junkan. Respiration & circulation,
K J Anderson, and J M Harten, and M G Booth, and C Berry, and A McConnachie, and A C Rankin, and J Kinsella
Heart rate regularisation in patients with permanent atrial fibrillation implanted with a VVI(R) pacemaker.
May 2004, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
K J Anderson, and J M Harten, and M G Booth, and C Berry, and A McConnachie, and A C Rankin, and J Kinsella
[Normobaric hyperoxia in the rat].
January 1967, Anesthesie, analgesie, reanimation,
K J Anderson, and J M Harten, and M G Booth, and C Berry, and A McConnachie, and A C Rankin, and J Kinsella
[Pulmonary toxicity caused by normobaric hyperoxia].
January 1987, Anales de la Real Academia Nacional de Medicina,
K J Anderson, and J M Harten, and M G Booth, and C Berry, and A McConnachie, and A C Rankin, and J Kinsella
Hemodynamic effects of adrenaline, noradrenaline and isopropylnoradrenaline in patients with a fixed rate artificial pacemaker.
May 1971, Acta medica Scandinavica,
K J Anderson, and J M Harten, and M G Booth, and C Berry, and A McConnachie, and A C Rankin, and J Kinsella
Ventricular demand pacemaker inhibition by an atrial fixed rate pacemaker.
September 1972, Chest,
K J Anderson, and J M Harten, and M G Booth, and C Berry, and A McConnachie, and A C Rankin, and J Kinsella
[Normobaric hyperoxia therapy for patients with traumatic brain injury].
March 2012, Annales francaises d'anesthesie et de reanimation,
Copied contents to your clipboard!