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Antigens associated with the surface of merozoites of the malaria parasite Plasmodium falciparum are directly accessible to immune attack and therefore are prime vaccine candidates. We have previously shown that one of the two known merozoite surface antigens (merozoite surface antigen 2; MSA-2) exhibits considerable sequence and antigenic diversity in different isolates. The sequences of MSA-2 from three isolates revealed a central domain composed of repeats that vary in number, length, and sequence, flanked in turn by nonrepetitive variable sequences and by conserved N- and C-terminal domains. We report here the sequences of a further four MSA-2 alleles, containing repetitive sequences that are related but not identical to each other. The seven alleles of MSA-2 can be divided into two distinct allele families on the basis of nonrepetitive sequences. Hybridization studies with repeat probes indicated that all of the 44 P. falciparum isolates examined contained repeat regions similar to those defined in known MSA-2 sequences.
J A Smythe, and
R L Coppel, and
K P Day, and
R K Martin, and
A M Oduola, and
D J Kemp, and
R F Anders
August 1997,
Journal of molecular evolution,
J A Smythe, and
R L Coppel, and
K P Day, and
R K Martin, and
A M Oduola, and
D J Kemp, and
R F Anders
December 1990,
Parasitology today (Personal ed.),
J A Smythe, and
R L Coppel, and
K P Day, and
R K Martin, and
A M Oduola, and
D J Kemp, and
R F Anders
October 1995,
Molecular and biochemical parasitology,
J A Smythe, and
R L Coppel, and
K P Day, and
R K Martin, and
A M Oduola, and
D J Kemp, and
R F Anders
March 1986,
Molecular and cellular biology,
J A Smythe, and
R L Coppel, and
K P Day, and
R K Martin, and
A M Oduola, and
D J Kemp, and
R F Anders
August 1995,
Experimental parasitology,
J A Smythe, and
R L Coppel, and
K P Day, and
R K Martin, and
A M Oduola, and
D J Kemp, and
R F Anders
October 2013,
Asian Pacific journal of tropical medicine,
J A Smythe, and
R L Coppel, and
K P Day, and
R K Martin, and
A M Oduola, and
D J Kemp, and
R F Anders
April 2004,
Infection and immunity,
J A Smythe, and
R L Coppel, and
K P Day, and
R K Martin, and
A M Oduola, and
D J Kemp, and
R F Anders
January 1992,
Molecular and biochemical parasitology,
J A Smythe, and
R L Coppel, and
K P Day, and
R K Martin, and
A M Oduola, and
D J Kemp, and
R F Anders
December 1997,
Molecular and biochemical parasitology,
J A Smythe, and
R L Coppel, and
K P Day, and
R K Martin, and
A M Oduola, and
D J Kemp, and
R F Anders
January 2003,
European journal of biochemistry,
