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A DNA restriction fragment with convergent SP6 and T7 promoters has undergone reaction with cis-diamminedichloroplatinum(II) (cis-DDP) and was then used as a template for RNA synthesis in vitro. The T7 and SP6 RNA polymerases generate fragments of defined sizes. Analysis of the RNA fragments shows that the polymerases are mainly blocked at the level of the d(GG) and d(AG) sites and to a lesser extent at the level of the d(GC) sites. The adducts at the d(GC) sites are more resistant to cyanide ion attack than those at the major sites and are identified as interstrand cross-links. The formation of an interstrand cross-link between the N-7 atoms of two guanine residues at the d(GC) sites was further confirmed by chemical modifications.
M A Lemaire, and
A Schwartz, and
A R Rahmouni, and
M Leng
June 1993,
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M A Lemaire, and
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M Leng
November 1987,
Biochemistry,
M A Lemaire, and
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M Leng
February 1997,
Nucleic acids research,
M A Lemaire, and
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M Leng
January 1990,
Acta biochimica Polonica,
M A Lemaire, and
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M Leng
June 1995,
Bioorganic & medicinal chemistry,
M A Lemaire, and
A Schwartz, and
A R Rahmouni, and
M Leng
September 1994,
Nucleic acids research,
M A Lemaire, and
A Schwartz, and
A R Rahmouni, and
M Leng
October 1983,
Cancer research,
M A Lemaire, and
A Schwartz, and
A R Rahmouni, and
M Leng
September 1995,
Biochemistry,
M A Lemaire, and
A Schwartz, and
A R Rahmouni, and
M Leng
March 1982,
Chemico-biological interactions,
M A Lemaire, and
A Schwartz, and
A R Rahmouni, and
M Leng
October 1996,
Nucleic acids research,
