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The present study shows that in a group of 6 euadrenal patients, previously treated by complete adrenalectomy for pituitary dependent Cushing's syndrome, the stress stimulus of insulin induced hypoglycaemia is followed by a plasma ACTH response which is of similar magnitude as the response obtained with lysin-vasopressin. Both observations indicate that the central nervous system-pituitary axis is basically normal in pituitary dependent Cushing's syndrome as assessed by insulin induced hypoglycaemia. It is concluded that non-responsiveness of the pituitary-adrenocortical system to insulin induced hypoglycaemia in untreated patients with pituitary dependent Cushing's syndrome does not represent a fundamental defect of the stress mechanism, but is due to hypercorticism per se.
R J Croughs, and
H Timmermans, and
A C Vingerhoeds, and
A Vermeulen, and
A Smals, and
P W Kloppenborg, and
J C Meyer
November 1992,
The Journal of clinical endocrinology and metabolism,
R J Croughs, and
H Timmermans, and
A C Vingerhoeds, and
A Vermeulen, and
A Smals, and
P W Kloppenborg, and
J C Meyer
October 1959,
Lancet (London, England),
R J Croughs, and
H Timmermans, and
A C Vingerhoeds, and
A Vermeulen, and
A Smals, and
P W Kloppenborg, and
J C Meyer
October 1965,
Archives of internal medicine,
R J Croughs, and
H Timmermans, and
A C Vingerhoeds, and
A Vermeulen, and
A Smals, and
P W Kloppenborg, and
J C Meyer
June 1984,
World journal of surgery,
R J Croughs, and
H Timmermans, and
A C Vingerhoeds, and
A Vermeulen, and
A Smals, and
P W Kloppenborg, and
J C Meyer
July 1993,
Postgraduate medical journal,
R J Croughs, and
H Timmermans, and
A C Vingerhoeds, and
A Vermeulen, and
A Smals, and
P W Kloppenborg, and
J C Meyer
January 1995,
The Journal of clinical endocrinology and metabolism,
R J Croughs, and
H Timmermans, and
A C Vingerhoeds, and
A Vermeulen, and
A Smals, and
P W Kloppenborg, and
J C Meyer
October 1973,
Virchows Archiv. A, Pathology. Pathologische Anatomie,
R J Croughs, and
H Timmermans, and
A C Vingerhoeds, and
A Vermeulen, and
A Smals, and
P W Kloppenborg, and
J C Meyer
December 1959,
Proceedings of the Royal Society of Medicine,
R J Croughs, and
H Timmermans, and
A C Vingerhoeds, and
A Vermeulen, and
A Smals, and
P W Kloppenborg, and
J C Meyer
December 2002,
Medizinische Klinik (Munich, Germany : 1983),
R J Croughs, and
H Timmermans, and
A C Vingerhoeds, and
A Vermeulen, and
A Smals, and
P W Kloppenborg, and
J C Meyer
May 1971,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
