Blockade of dopamine, but not noradrenaline, transporters produces hyperthermia in rats that lack serotonin transporters. 2010

Jocelien D A Olivier, and Alexander R Cools, and Peter M T Deen, and Berend Olivier, and Bart A Ellenbroek
Donders Institute for Brain, Cognition and Behaviour: Department of Cognitive Neuroscience: Molecular Neurobiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. j.olivier@cns.umcn.nl

To investigate whether life-long disturbed serotonin neurotransmission may result in adaptive changes of dopaminergic and noradrenergic systems, effects of drugs on stress-induced hyperthermia were studied in serotonin transporter knockout rats. The noradrenalin transporter blocker atomoxetine was more effective in reducing stress-induced hyperthermia, induced by an injection, in serotonin transporter (SERT) knockout (SERT(-/-)) rats compared to SERT(+/+) rats. The dopamine transporter blocker GBR12909 increased the core body temperature in SERT(-/-) rats, and had no effect on the SERT(+/+) rats. Finally, the noradrenalin transporter together with dopamine transporter blocker bupropion was more effective in decreasing the stress of an injection in SERT(-/-) rats than in SERT(+/+) rats. These data suggest that the sensitivity of dopamine and noradrenalin receptors is changed in serotonin transporter knockout rats. The lack of the serotonin transporter in SERT(-/-) rats might reflect humans with a life-long disturbed serotonin system, making this rat a good model to study possible changes in dopaminergic and noradrenergic systems in psychiatric disorders.

UI MeSH Term Description Entries
D007267 Injections Introduction of substances into the body using a needle and syringe. Injectables,Injectable,Injection
D008297 Male Males
D010879 Piperazines Compounds that are derived from PIPERAZINE.
D011437 Propylamines Derivatives of propylamine (the structural formula NH2CH2CH2CH3).
D001831 Body Temperature The measure of the level of heat of a human or animal. Organ Temperature,Body Temperatures,Organ Temperatures,Temperature, Body,Temperature, Organ,Temperatures, Body,Temperatures, Organ
D005334 Fever An abnormal elevation of body temperature, usually as a result of a pathologic process. Pyrexia,Fevers,Pyrexias
D000069445 Atomoxetine Hydrochloride A propylamine derivative and selective ADRENERGIC UPTAKE INHIBITOR that is used in the treatment of ATTENTION DEFICIT HYPERACTIVITY DISORDER. Atomoxetine,Atomoxetine HCl,LY 139603,N-methyl-gamma-(2-methylphenoxy)benzenepropanamine hydrochloride,Strattera,Tomoxetine,Tomoxetine Hydrochloride, (+)-isomer - T351671,Tomoxetine Hydrochloride, (+-)-isomer,Tomoxetine Hydrochloride, (-)-isomer,139603, LY,HCl, Atomoxetine,Hydrochloride, Atomoxetine
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013312 Stress, Physiological The unfavorable effect of environmental factors (stressors) on the physiological functions of an organism. Prolonged unresolved physiological stress can affect HOMEOSTASIS of the organism, and may lead to damaging or pathological conditions. Biotic Stress,Metabolic Stress,Physiological Stress,Abiotic Stress,Abiotic Stress Reaction,Abiotic Stress Response,Biological Stress,Metabolic Stress Response,Physiological Stress Reaction,Physiological Stress Reactivity,Physiological Stress Response,Abiotic Stress Reactions,Abiotic Stress Responses,Abiotic Stresses,Biological Stresses,Biotic Stresses,Metabolic Stress Responses,Metabolic Stresses,Physiological Stress Reactions,Physiological Stress Responses,Physiological Stresses,Reaction, Abiotic Stress,Reactions, Abiotic Stress,Response, Abiotic Stress,Response, Metabolic Stress,Stress Reaction, Physiological,Stress Response, Metabolic,Stress Response, Physiological,Stress, Abiotic,Stress, Biological,Stress, Biotic,Stress, Metabolic
D016642 Bupropion A propiophenone-derived antidepressant and antismoking agent that inhibits the uptake of DOPAMINE. (+-)-1-(3-Chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone,Amfebutamone,Bupropion Hydrochloride,Bupropion Hydrochloride, (+-)-Isomer,Bupropion, (+-)-Isomer,Quomen,Wellbutrin,Zyban (Anti-Smoking),Zyban (Bupropion),Zyntabac

Related Publications

Jocelien D A Olivier, and Alexander R Cools, and Peter M T Deen, and Berend Olivier, and Bart A Ellenbroek
November 2014, European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology,
Jocelien D A Olivier, and Alexander R Cools, and Peter M T Deen, and Berend Olivier, and Bart A Ellenbroek
August 2009, Psychopharmacology,
Jocelien D A Olivier, and Alexander R Cools, and Peter M T Deen, and Berend Olivier, and Bart A Ellenbroek
July 1996, European journal of pharmacology,
Jocelien D A Olivier, and Alexander R Cools, and Peter M T Deen, and Berend Olivier, and Bart A Ellenbroek
June 1999, Neuropharmacology,
Jocelien D A Olivier, and Alexander R Cools, and Peter M T Deen, and Berend Olivier, and Bart A Ellenbroek
October 2005, Neuroscience letters,
Jocelien D A Olivier, and Alexander R Cools, and Peter M T Deen, and Berend Olivier, and Bart A Ellenbroek
April 2005, Journal of neurochemistry,
Jocelien D A Olivier, and Alexander R Cools, and Peter M T Deen, and Berend Olivier, and Bart A Ellenbroek
December 1996, Alcoholism, clinical and experimental research,
Jocelien D A Olivier, and Alexander R Cools, and Peter M T Deen, and Berend Olivier, and Bart A Ellenbroek
June 2015, Behavioural pharmacology,
Jocelien D A Olivier, and Alexander R Cools, and Peter M T Deen, and Berend Olivier, and Bart A Ellenbroek
October 2007, European journal of pharmacology,
Jocelien D A Olivier, and Alexander R Cools, and Peter M T Deen, and Berend Olivier, and Bart A Ellenbroek
August 2021, Drug development research,
Copied contents to your clipboard!