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Cartilage degeneration in osteoarthritis is initiated by a loss of proteoglycan. Intra-articular injection of papain causes a reversible loss of proteoglycan in rabbit knees. Rabbits were scanned with magnetic resonance imaging (MRI), using a 1.5T Signa superconducting magnet with 3 inch surface coil. Spin echo sequences were performed in the coronal and sagittal planes at 0, 24, 48, and 72 h after intra-articular injection of papain to obtain T1, proton density, and T2-weighted images. Cartilage proteoglycan content was measured biochemically and histochemically. Reduced articular cartilage thickness in the MR images of papain-treated knees corresponded to changes in cartilage proteoglycan content.
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E O'Byrne, and
V Blancuzzi, and
D Wilson, and
D Gunson, and
F L Douglas, and
J Z Wang, and
R S Mezrich
May 1997,
Magnetic resonance in medicine,
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E O'Byrne, and
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R S Mezrich
December 1998,
Topics in magnetic resonance imaging : TMRI,
P K Paul, and
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February 2018,
The journal of knee surgery,
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January 2001,
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Clinical orthopaedics and related research,
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Magma (New York, N.Y.),
P K Paul, and
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R S Mezrich
April 1988,
Arthritis and rheumatism,
P K Paul, and
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D Gunson, and
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R S Mezrich
January 1991,
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P K Paul, and
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Current opinion in rheumatology,
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Journal of orthopaedic research : official publication of the Orthopaedic Research Society,
