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Bio-resolution of glycidyl (o, m, p)-methylphenyl ethers by Bacillus megaterium. 2010

Zhengfang Zhang, and Yanming Sheng, and Keyi Jiang, and Zhao Wang, and Yuguo Zheng, and Qing Zhu
College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou, 310014 People's Republic of China.

A newly isolated Bacillus megaterium with epoxide hydrolase activity resolved racemic glycidyl (o, m, p)-methylphenyl ethers to give enantiopure epoxides in 84-99% enantiomeric excess and with 21-73 enantiomeric ratios. The (S)-enantiomer was obtained from rac-glycidyl (o or m)-methylphenyl ether while the (R)-epoxides was obtained from glycidyl p-methylphenyl ether. The observations are explained at the level by enzyme-substrate docking studies.

UI MeSH Term Description Entries
D007700 Kinetics The rate dynamics in chemical or physical systems.
D004852 Epoxy Compounds Organic compounds that include a cyclic ether with three ring atoms in their structure. They are commonly used as precursors for POLYMERS such as EPOXY RESINS. Epoxide,Epoxides,Epoxy Compound,Oxiranes,Compound, Epoxy,Compounds, Epoxy
D006868 Hydrolysis The process of cleaving a chemical compound by the addition of a molecule of water.
D000840 Anisoles A group of compounds that are derivatives of methoxybenzene and contain the general formula R-C7H7O. Methylphenyl Ethers,Ethers, Methylphenyl
D001410 Bacillus megaterium A species of bacteria whose spores vary from round to elongate. It is a common soil saprophyte. Bacillus megatherium
D013237 Stereoisomerism The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed) Molecular Stereochemistry,Stereoisomers,Stereochemistry, Molecular,Stereoisomer

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