-transparent.png){kind=logo}
Because the cholesterol-rich very low density (VLD) lipoproteins of subjects with type III hyperlipoproteinemia are distinctively enriched in apolipoprotein E, a radial immunodiffusion assay for apolipoprotein E in whole plasma was developed. Its diagnostic usefulness was tested in randomly selected (n = 174) and hyperlipidemic (n = 61) subsets of an adult employee population and a hyperlipidemia clinic referral group (n = 63), which included 18 patients with well-documented type III hyperlipoproteinemia. Apolipoprotein-E levels were normally distributed among the random population subset, were equal between the two sexes, and increased little with age. The mean and 99th percentile values were 24.6 and 40.1 mg/dl, respectively. All subjects with type III patterns as assigned by standard criteria from both population (n = 4) and referral sources exceeded this 99th percentile (chi +/- SD = 54.7 +/- 9.7 mg/dl). Hence a plasma apolipoprotein-E concentration exceeding 40 mg/dl appears diagnostic of type III hyperlipoproteinemia, representing the first application of an apolipoprotein immunoassay to improved diagnosis of the hyperlipoproteinemias.
R S Kushwaha, and
W R Hazzard, and
P W Wahl, and
J J Hoover
January 1998,
Ryoikibetsu shokogun shirizu,
R S Kushwaha, and
W R Hazzard, and
P W Wahl, and
J J Hoover
December 1981,
Science (New York, N.Y.),
R S Kushwaha, and
W R Hazzard, and
P W Wahl, and
J J Hoover
February 2006,
Rinsho byori. The Japanese journal of clinical pathology,
R S Kushwaha, and
W R Hazzard, and
P W Wahl, and
J J Hoover
November 1985,
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete,
R S Kushwaha, and
W R Hazzard, and
P W Wahl, and
J J Hoover
April 1995,
Journal of investigative medicine : the official publication of the American Federation for Clinical Research,
R S Kushwaha, and
W R Hazzard, and
P W Wahl, and
J J Hoover
August 2007,
Journal of clinical lipidology,
R S Kushwaha, and
W R Hazzard, and
P W Wahl, and
J J Hoover
February 1981,
Science (New York, N.Y.),
R S Kushwaha, and
W R Hazzard, and
P W Wahl, and
J J Hoover
January 1979,
Clinical genetics,
R S Kushwaha, and
W R Hazzard, and
P W Wahl, and
J J Hoover
March 1993,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
R S Kushwaha, and
W R Hazzard, and
P W Wahl, and
J J Hoover
October 1989,
Biochimica et biophysica acta,
