Biomaterial Database

The neural cell adhesion molecule NCAM and lipid rafts. 2010

Gro Klitgaard Povlsen, and Dorte Kornerup Ditlevsen

ENKAM Pharmaceuticals, Fruebjergvej 3, 2100 Copenhagen Ø, Denmark. grkpo01@glo.regionh.dk

UI	MeSH Term	Description	Entries
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013049	Spectrin	A high molecular weight (220-250 kDa) water-soluble protein which can be extracted from erythrocyte ghosts in low ionic strength buffers. The protein contains no lipids or carbohydrates, is the predominant species of peripheral erythrocyte membrane proteins, and exists as a fibrous coating on the inner, cytoplasmic surface of the membrane.	alpha-Spectrin,beta-Spectrin,alpha Spectrin,beta Spectrin
D015398	Signal Transduction	The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.	Cell Signaling,Receptor-Mediated Signal Transduction,Signal Pathways,Receptor Mediated Signal Transduction,Signal Transduction Pathways,Signal Transduction Systems,Pathway, Signal,Pathway, Signal Transduction,Pathways, Signal,Pathways, Signal Transduction,Receptor-Mediated Signal Transductions,Signal Pathway,Signal Transduction Pathway,Signal Transduction System,Signal Transduction, Receptor-Mediated,Signal Transductions,Signal Transductions, Receptor-Mediated,System, Signal Transduction,Systems, Signal Transduction,Transduction, Signal,Transductions, Signal
D051076	Proto-Oncogene Proteins c-fyn	Src-family kinases that associate with T-CELL ANTIGEN RECEPTOR and phosphorylate a wide variety of intracellular signaling molecules.	Proto-Oncogene Protein p60(fyn),c-fyn Protein,fyn Proto-Oncogene Proteins,Fyn Tyrosine Kinase,Protein-Tyrosine Kinase p59(fyn),Proto-Oncogene Protein c-fyn,Proto-Oncogene Protein c-syn,Proto-Oncogene Protein p59(fyn),Proto-Oncogene Protein p72(fyn),c-fyn Proto-Oncogene Proteins,p59 c-fyn Protein,p59(fyn) Protein,p60 c-fyn Protein,p60(fyn) Protein,p72 c-fyn Protein,p72(fyn) Protein,Proteins c-fyn, Proto-Oncogene,Proto Oncogene Protein c fyn,Proto Oncogene Protein c syn,Proto Oncogene Proteins c fyn,Proto-Oncogene Proteins, c-fyn,Proto-Oncogene Proteins, fyn,Tyrosine Kinase, Fyn,c fyn Proto Oncogene Proteins,c-fyn Protein, p59,c-fyn Protein, p60,c-fyn, Proto-Oncogene Protein,c-fyn, Proto-Oncogene Proteins,c-syn, Proto-Oncogene Protein,fyn Proto Oncogene Proteins,p59 c fyn Protein,p60 c fyn Protein,p72 c fyn Protein
D054630	Receptor-Like Protein Tyrosine Phosphatases, Class 4	A subclass of receptor-like protein tryosine phosphatases that contain short highly glycosylated extracellular domains and two active cytosolic protein tyrosine phosphatase domains.	Protein Tyrosine Phosphatase, Receptor Type A,Protein Tyrosine Phosphatase, Receptor Type E,Protein-Tyrosine Phosphatase alpha,Protein-Tyrosine Phosphatase epsilon,R-PTP-alpha Phosphatase,R-PTP-epsilon,Receptor-Like Protein Tyrosine Phosphatases, Class IV,Phosphatase alpha, Protein-Tyrosine,Phosphatase epsilon, Protein-Tyrosine,Phosphatase, R-PTP-alpha,Protein Tyrosine Phosphatase alpha,Protein Tyrosine Phosphatase epsilon,R PTP alpha Phosphatase,R PTP epsilon,Receptor Like Protein Tyrosine Phosphatases, Class 4,Receptor Like Protein Tyrosine Phosphatases, Class IV
D019006	Neural Cell Adhesion Molecules	Cell adhesion molecule involved in a diverse range of contact-mediated interactions among neurons, astrocytes, oligodendrocytes, and myotubes. It is widely but transiently expressed in many tissues early in embryogenesis. Four main isoforms exist, including CD56; (CD56 ANTIGEN); but there are many other variants resulting from alternative splicing and post-translational modifications. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, pp115-119)	Cell Adhesion Molecule, Neural,NCAM,Neural Cell Adhesion Molecule,Cell Adhesion Molecules, Neural
D019922	GAP-43 Protein	A nervous tissue specific protein which is highly expressed in NEURONS during development and NERVE REGENERATION. It has been implicated in neurite outgrowth, long-term potentiation, SIGNAL TRANSDUCTION, and NEUROTRANSMITTER release. (From Neurotoxicology 1994;15(1):41-7) It is also a substrate of PROTEIN KINASE C.	B-50 Protein,GAP-43,Growth-Associated Protein 43,Nerve Growth Cone Membrane Protein GAP-43,Neuromodulin,GAP43 Protein,Phosphoprotein B-50,Phosphoprotein F1,Phosphoprotein pp46,B 50 Protein,GAP 43 Protein,Growth Associated Protein 43,Nerve Growth Cone Membrane Protein GAP 43,Phosphoprotein B 50
D020033	Protein Isoforms	Different forms of a protein that may be produced from different GENES, or from the same gene by ALTERNATIVE SPLICING.	Isoform,Isoforms,Protein Isoform,Protein Splice Variant,Splice Variants, Protein,Protein Splice Variants,Isoform, Protein,Isoforms, Protein,Splice Variant, Protein,Variant, Protein Splice,Variants, Protein Splice
D021962	Membrane Microdomains	Detergent-insoluble CELL MEMBRANE components. They are enriched in SPHINGOLIPIDS and CHOLESTEROL and clustered with glycosyl-phosphatidylinositol (GPI)-anchored proteins.	Lipid Rafts, Cell Membrane,Sphingolipid Microdomains,Sphingolipid-Cholesterol Rafts,Membrane Microdomain,Microdomain, Membrane,Microdomain, Sphingolipid,Microdomains, Membrane,Microdomains, Sphingolipid,Sphingolipid Cholesterol Rafts,Sphingolipid Microdomain,Sphingolipid-Cholesterol Raft