-transparent.png){kind=logo}
1. The metabolism of chlorpheniramine (I) was examined in vivo in rats and a human volunteer; in the rats a stable isotope was used. 2. In addition to the unchanged drug (I) and the N-demethylated metabolites (II and III), nine further metabolites were identified in rat urine, four of which were also found in human urine. Chlorpheniramine N-oxide (IV), 3-(p-chlorophenyl)-3-(2-pyridyl) propanol (V), 3-(p-chlorophenyl)-3-(2-pyridyl)-N-acetylaminopropane (VII) and 3-(p-chlorophenyl)-3-(2-pyridyl)-propionic acid (XIII) were identified in rat and human urine. 3. The hydroxylated metabolites of the pyridyl ring of the unchanged drug, II, V and VII, and the glucuronide of XIII were identified only in rat urine. XIII was found in rat urine as long as 6 days after the last dose.
F Kasuya, and
K Igarashi, and
M Fukui
December 2001,
Nutrition research reviews,
F Kasuya, and
K Igarashi, and
M Fukui
June 2001,
Seminars in perinatology,
F Kasuya, and
K Igarashi, and
M Fukui
January 1985,
Annales d'endocrinologie,
F Kasuya, and
K Igarashi, and
M Fukui
September 1988,
The Proceedings of the Nutrition Society,
F Kasuya, and
K Igarashi, and
M Fukui
March 1969,
Biochemical pharmacology,
F Kasuya, and
K Igarashi, and
M Fukui
September 1982,
Radioisotopes,
F Kasuya, and
K Igarashi, and
M Fukui
July 1978,
Life sciences,
F Kasuya, and
K Igarashi, and
M Fukui
July 1994,
The Proceedings of the Nutrition Society,
F Kasuya, and
K Igarashi, and
M Fukui
January 1990,
Beitrage zur Infusionstherapie = Contributions to infusion therapy,
F Kasuya, and
K Igarashi, and
M Fukui
March 2020,
European journal of clinical nutrition,
