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To our knowledge, placental transfer of pentamidine has not been previously studied in vivo. In the present study, the pharmacokinetics of pentamidine were analyzed in late gestation (18 days) among Sprague-Dawley rats. Pentamidine's kinetics were assessed in the following maternal compartments over a 12-hour period in 16 timed-pregnant rats: serum, liver, and kidney. Placentas were also analyzed for pentamidine concentration as were fetal brain, liver, and kidney tissues. Significant placental transfer of the drug was found, with pentamidine reaching all fetal compartments studied. Notably, by the twelfth hour fetal brain tissue achieved pentamidine concentrations that were not significantly different from those of maternal serum at the second hour of the experiment. This is an interesting observation because adult mouse and rat brains were found to be unexposed to the drug.
B B Little, and
T H Harstad, and
R E Bawdon, and
S Sobhi, and
D A Roe, and
K A Knoll, and
F E Ghali
April 2006,
Inhalation toxicology,
B B Little, and
T H Harstad, and
R E Bawdon, and
S Sobhi, and
D A Roe, and
K A Knoll, and
F E Ghali
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B B Little, and
T H Harstad, and
R E Bawdon, and
S Sobhi, and
D A Roe, and
K A Knoll, and
F E Ghali
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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
B B Little, and
T H Harstad, and
R E Bawdon, and
S Sobhi, and
D A Roe, and
K A Knoll, and
F E Ghali
September 2010,
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B B Little, and
T H Harstad, and
R E Bawdon, and
S Sobhi, and
D A Roe, and
K A Knoll, and
F E Ghali
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Journal of veterinary pharmacology and therapeutics,
B B Little, and
T H Harstad, and
R E Bawdon, and
S Sobhi, and
D A Roe, and
K A Knoll, and
F E Ghali
September 1995,
Annals of the New York Academy of Sciences,
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T H Harstad, and
R E Bawdon, and
S Sobhi, and
D A Roe, and
K A Knoll, and
F E Ghali
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B B Little, and
T H Harstad, and
R E Bawdon, and
S Sobhi, and
D A Roe, and
K A Knoll, and
F E Ghali
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B B Little, and
T H Harstad, and
R E Bawdon, and
S Sobhi, and
D A Roe, and
K A Knoll, and
F E Ghali
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Journal of the American Association for Laboratory Animal Science : JAALAS,
B B Little, and
T H Harstad, and
R E Bawdon, and
S Sobhi, and
D A Roe, and
K A Knoll, and
F E Ghali
April 2023,
Cannabis and cannabinoid research,
