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We quantitated in vivo migration of neutrophils into the knees of patients with rheumatoid arthritis (RA) and osteoarthritis, using 99mtechnetium-hexamethyl-propylene-amineoxime-labeled leukocytes and gamma scintigraphy. Significant neutrophil migration occurred in patients with RA irrespective of disease duration, and it was reduced by 60% following intraarticular steroid injection. The reduction in neutrophil migration correlated with reduction in pain. Leukocyte migration into osteoarthritic joints was also demonstrated, although it was much less than that seen in rheumatoid joints. No significant leukocyte migration into the joints of patients without arthritis was demonstrated. This technique appears to provide a sensitive method for quantitatively assessing the neutrophil component of inflammation in individual joints of patients with arthritis.
A K Jones, and
M A al-Janabi, and
K Solanki, and
R Sobnack, and
A Greenwood, and
D V Doyle, and
K E Britton, and
E C Huskisson
October 2013,
Current opinion in cell biology,
A K Jones, and
M A al-Janabi, and
K Solanki, and
R Sobnack, and
A Greenwood, and
D V Doyle, and
K E Britton, and
E C Huskisson
January 2022,
Methods in molecular biology (Clifton, N.J.),
A K Jones, and
M A al-Janabi, and
K Solanki, and
R Sobnack, and
A Greenwood, and
D V Doyle, and
K E Britton, and
E C Huskisson
December 1972,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
A K Jones, and
M A al-Janabi, and
K Solanki, and
R Sobnack, and
A Greenwood, and
D V Doyle, and
K E Britton, and
E C Huskisson
December 1982,
Inflammation,
A K Jones, and
M A al-Janabi, and
K Solanki, and
R Sobnack, and
A Greenwood, and
D V Doyle, and
K E Britton, and
E C Huskisson
December 1975,
The Journal of laboratory and clinical medicine,
A K Jones, and
M A al-Janabi, and
K Solanki, and
R Sobnack, and
A Greenwood, and
D V Doyle, and
K E Britton, and
E C Huskisson
October 2005,
Proceedings of the National Academy of Sciences of the United States of America,
A K Jones, and
M A al-Janabi, and
K Solanki, and
R Sobnack, and
A Greenwood, and
D V Doyle, and
K E Britton, and
E C Huskisson
January 1991,
Laboratornoe delo,
A K Jones, and
M A al-Janabi, and
K Solanki, and
R Sobnack, and
A Greenwood, and
D V Doyle, and
K E Britton, and
E C Huskisson
December 2010,
Journal of visualized experiments : JoVE,
A K Jones, and
M A al-Janabi, and
K Solanki, and
R Sobnack, and
A Greenwood, and
D V Doyle, and
K E Britton, and
E C Huskisson
May 1980,
Klinicheskaia meditsina,
A K Jones, and
M A al-Janabi, and
K Solanki, and
R Sobnack, and
A Greenwood, and
D V Doyle, and
K E Britton, and
E C Huskisson
January 1984,
Nihon Seikeigeka Gakkai zasshi,
