Olanzapine induced tardive dystonia. 2008

Ashish Aggarwal, and R C Jiloha
Department of Psychiatry, G. B. Pant Hospital and Maulana Azad Medical College, New Delhi, India.

Advent of atypical antipsychotics was thought to be a major advancement in the psychopharmacology for schizophrenia. It was thought that these drugs would have low propensity to induce extrapyramidal symptoms including tardive movements. Olanzapine is a thienobenzodiazepine derivative, second generation (atypical) antipsychotic agent. Compared to typical antipsychotics, it has a greater affinity for serotonin 5-HT2A than dopamine D2 receptors, with preferential action at mesolimbic than nigrostriatal dopaminergic pathways. However, only few reports of olanzapine induced tardive dystonia (TD) are available in the literature. We wish to report another case of TD, in a male patient with schizophrenia, which developed after 15 months of treatment with olanzapine.

UI MeSH Term Description Entries

Related Publications

Ashish Aggarwal, and R C Jiloha
October 1999, The American journal of psychiatry,
Ashish Aggarwal, and R C Jiloha
April 2014, The Journal of neuropsychiatry and clinical neurosciences,
Ashish Aggarwal, and R C Jiloha
January 2007, The Journal of neuropsychiatry and clinical neurosciences,
Ashish Aggarwal, and R C Jiloha
February 2014, Shanghai archives of psychiatry,
Ashish Aggarwal, and R C Jiloha
December 1999, The American journal of psychiatry,
Ashish Aggarwal, and R C Jiloha
August 2001, Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology,
Ashish Aggarwal, and R C Jiloha
January 2009, Journal of pediatric neurosciences,
Ashish Aggarwal, and R C Jiloha
February 2004, Schizophrenia research,
Ashish Aggarwal, and R C Jiloha
January 2004, Journal of child and adolescent psychopharmacology,
Ashish Aggarwal, and R C Jiloha
January 2002, Clinical neuropharmacology,
Copied contents to your clipboard!