Protective effect of an herbal preparation (HemoHIM) on radiation-induced intestinal injury in mice. 2009

Sung Ho Kim, and Hae June Lee, and Joong Sun Kim, and Changjong Moon, and Jong Choon Kim, and Hae-Ran Park, and Uhee Jung, and Jong Sik Jang, and Sung Kee Jo
College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea.

The protective properties of an herbal preparation (HemoHIM) against intestinal damage were examined by evaluating its effects on jejunal crypt survival, morphological changes, and apoptosis in gamma-irradiated mice. The mice were whole-body irradiated with 12 Gy for the examination of jejunal crypt survival and any morphological changes and with 2 Gy for the detection of apoptosis and Ki-67 labeling. Irradiation was conducted using (60)Co gamma-rays. HemoHIM treatment was administered intraperitonially at a dosage of 50 mg/kg of body weight at 36 and 12 hours pre-irradiation and 30 minutes post-irradiation or orally at a dosage of 250 mg/kg of body weight/day for 7 or 11 days before necropsy. The HemoHIM-treated group displayed a significant increase in survival of jejunal crypts, when compared to the irradiation controls. HemoHIM treatment decreased intestinal morphological changes such as crypt depth, villus height, mucosal length, and basal lamina length of 10 enterocytes after irradiation. Furthermore, the administration of HemoHIM protected intestinal cells from irradiation-induced apoptosis. These results suggested that HemoHIM may be therapeutically useful to reduce intestinal injury following irradiation.

UI MeSH Term Description Entries
D007422 Intestines The section of the alimentary canal from the STOMACH to the ANAL CANAL. It includes the LARGE INTESTINE and SMALL INTESTINE. Intestine
D008813 Mice, Inbred ICR An inbred strain of mouse that is used as a general purpose research strain, for therapeutic drug testing, and for the genetic analysis of CARCINOGEN-induced COLON CANCER. Mice, Inbred ICRC,Mice, ICR,Mouse, ICR,Mouse, Inbred ICR,Mouse, Inbred ICRC,ICR Mice,ICR Mice, Inbred,ICR Mouse,ICR Mouse, Inbred,ICRC Mice, Inbred,ICRC Mouse, Inbred,Inbred ICR Mice,Inbred ICR Mouse,Inbred ICRC Mice,Inbred ICRC Mouse
D011832 Radiation Injuries Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in VERTEBRATES. Radiation Sickness,Radiation Syndrome,Injuries, Radiation,Injury, Radiation,Radiation Injury,Radiation Sicknesses,Radiation Syndromes,Sickness, Radiation,Sicknesses, Radiation,Syndrome, Radiation,Syndromes, Radiation
D011837 Radiation-Protective Agents Drugs used to protect against ionizing radiation. They are usually of interest for use in radiation therapy but have been considered for other purposes, e.g. military. Radiation Protectant,Radiation Protective Agent,Radiation-Protective Agent,Radiation-Protective Drug,Radioprotective Agent,Radioprotective Agents,Radioprotective Drug,Agents, Radiation-Protective,Radiation Protectants,Radiation Protective Agents,Radiation-Protective Drugs,Radiation-Protective Effect,Radiation-Protective Effects,Radioprotective Drugs,Agent, Radiation Protective,Agent, Radiation-Protective,Agent, Radioprotective,Agents, Radiation Protective,Agents, Radioprotective,Drug, Radiation-Protective,Drug, Radioprotective,Drugs, Radiation-Protective,Drugs, Radioprotective,Effect, Radiation-Protective,Effects, Radiation-Protective,Protectant, Radiation,Protectants, Radiation,Protective Agent, Radiation,Protective Agents, Radiation,Radiation Protective Drug,Radiation Protective Drugs,Radiation Protective Effect,Radiation Protective Effects
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D005260 Female Females
D005720 Gamma Rays Penetrating, high-energy electromagnetic radiation emitted from atomic nuclei during NUCLEAR DECAY. The range of wavelengths of emitted radiation is between 0.1 - 100 pm which overlaps the shorter, more energetic hard X-RAYS wavelengths. The distinction between gamma rays and X-rays is based on their radiation source. Gamma Wave,Gamma Radiation,Nuclear X-Rays,Radiation, Gamma,X-Rays, Nuclear,Gamma Radiations,Gamma Ray,Gamma Waves,Nuclear X Rays,Nuclear X-Ray,Ray, Gamma,Wave, Gamma,Waves, Gamma,X Rays, Nuclear,X-Ray, Nuclear
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus

Related Publications

Sung Ho Kim, and Hae June Lee, and Joong Sun Kim, and Changjong Moon, and Jong Choon Kim, and Hae-Ran Park, and Uhee Jung, and Jong Sik Jang, and Sung Kee Jo
May 2013, BMC complementary and alternative medicine,
Sung Ho Kim, and Hae June Lee, and Joong Sun Kim, and Changjong Moon, and Jong Choon Kim, and Hae-Ran Park, and Uhee Jung, and Jong Sik Jang, and Sung Kee Jo
February 2015, International journal of radiation biology,
Sung Ho Kim, and Hae June Lee, and Joong Sun Kim, and Changjong Moon, and Jong Choon Kim, and Hae-Ran Park, and Uhee Jung, and Jong Sik Jang, and Sung Kee Jo
June 2003, Journal of ethnopharmacology,
Sung Ho Kim, and Hae June Lee, and Joong Sun Kim, and Changjong Moon, and Jong Choon Kim, and Hae-Ran Park, and Uhee Jung, and Jong Sik Jang, and Sung Kee Jo
April 2019, Phytotherapy research : PTR,
Sung Ho Kim, and Hae June Lee, and Joong Sun Kim, and Changjong Moon, and Jong Choon Kim, and Hae-Ran Park, and Uhee Jung, and Jong Sik Jang, and Sung Kee Jo
January 2013, PloS one,
Sung Ho Kim, and Hae June Lee, and Joong Sun Kim, and Changjong Moon, and Jong Choon Kim, and Hae-Ran Park, and Uhee Jung, and Jong Sik Jang, and Sung Kee Jo
December 2020, Chemistry & biodiversity,
Sung Ho Kim, and Hae June Lee, and Joong Sun Kim, and Changjong Moon, and Jong Choon Kim, and Hae-Ran Park, and Uhee Jung, and Jong Sik Jang, and Sung Kee Jo
October 2022, Archives of biochemistry and biophysics,
Sung Ho Kim, and Hae June Lee, and Joong Sun Kim, and Changjong Moon, and Jong Choon Kim, and Hae-Ran Park, and Uhee Jung, and Jong Sik Jang, and Sung Kee Jo
January 2021, Dose-response : a publication of International Hormesis Society,
Sung Ho Kim, and Hae June Lee, and Joong Sun Kim, and Changjong Moon, and Jong Choon Kim, and Hae-Ran Park, and Uhee Jung, and Jong Sik Jang, and Sung Kee Jo
December 2018, Bioscience reports,
Sung Ho Kim, and Hae June Lee, and Joong Sun Kim, and Changjong Moon, and Jong Choon Kim, and Hae-Ran Park, and Uhee Jung, and Jong Sik Jang, and Sung Kee Jo
July 2015, Anticancer research,
Copied contents to your clipboard!