BIOMAT Database Logo BIOMAT Database Logo

Modifying effect of ascorbic acid and sodium ascorbate on the promoting stage of uterine sarcomogenesis induced in CBA mice by 1,2-dimethylhydrazine and estradiol-dipropionate. 1991

V S Turusov, and L S Trukhanova, and Parfenov YuD
Institute of Carcinogenesis, USSR Academy of Medical Sciences, Moscow.

Administration of estradiol-dipropionate (EP) after the cessation of 1,2-dimethylhydrazine (DMH) treatment increased the incidence of uterine sarcomas in CBA mice from 32.5 (DMH alone) to 62.5%. Ascorbic acid (AA) (0.3% in drinking water) given simultaneously with EP decreased the tumour incidence to 35%. Sodium ascorbate did not exert an inhibiting effect. AA inhibited the increase of uterine weight produced in mice by EP and did not influence the growth of mouse transplantable uterine sarcomas. The mechanisms of the antiestrogenic effects of AA are discussed.

UI MeSH Term Description Entries
D008808 Mice, Inbred CBA An inbred strain of mouse that is widely used in BIOMEDICAL RESEARCH. Mice, CBA,Mouse, CBA,Mouse, Inbred CBA,CBA Mice,CBA Mice, Inbred,CBA Mouse,CBA Mouse, Inbred,Inbred CBA Mice,Inbred CBA Mouse
D009929 Organ Size The measurement of an organ in volume, mass, or heaviness. Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D002273 Carcinogens Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included. Carcinogen,Oncogen,Oncogens,Tumor Initiator,Tumor Initiators,Tumor Promoter,Tumor Promoters,Initiator, Tumor,Initiators, Tumor,Promoter, Tumor,Promoters, Tumor
D004127 Dimethylhydrazines Hydrazines substituted with two methyl groups in any position. Dimethylhydrazine
D004336 Drug Antagonism Phenomena and pharmaceutics of compounds that inhibit the function of agonists (DRUG AGONISM) and inverse agonists (DRUG INVERSE AGONISM) for a specific receptor. On their own, antagonists produce no effect by themselves to a receptor, and are said to have neither intrinsic activity nor efficacy. Antagonism, Drug,Antagonisms, Drug,Drug Antagonisms
D004958 Estradiol The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. 17 beta-Estradiol,Estradiol-17 beta,Oestradiol,17 beta-Oestradiol,Aerodiol,Delestrogen,Estrace,Estraderm TTS,Estradiol Anhydrous,Estradiol Hemihydrate,Estradiol Hemihydrate, (17 alpha)-Isomer,Estradiol Monohydrate,Estradiol Valerate,Estradiol Valeriante,Estradiol, (+-)-Isomer,Estradiol, (-)-Isomer,Estradiol, (16 alpha,17 alpha)-Isomer,Estradiol, (16 alpha,17 beta)-Isomer,Estradiol, (17-alpha)-Isomer,Estradiol, (8 alpha,17 beta)-(+-)-Isomer,Estradiol, (8 alpha,17 beta)-Isomer,Estradiol, (9 beta,17 alpha)-Isomer,Estradiol, (9 beta,17 beta)-Isomer,Estradiol, Monosodium Salt,Estradiol, Sodium Salt,Estradiol-17 alpha,Estradiol-17beta,Ovocyclin,Progynon-Depot,Progynova,Vivelle,17 beta Estradiol,17 beta Oestradiol,Estradiol 17 alpha,Estradiol 17 beta,Estradiol 17beta,Progynon Depot
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001205 Ascorbic Acid A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant. Vitamin C,Ascorbic Acid, Monosodium Salt,Ferrous Ascorbate,Hybrin,L-Ascorbic Acid,Magnesium Ascorbate,Magnesium Ascorbicum,Magnesium di-L-Ascorbate,Magnorbin,Sodium Ascorbate,Acid, Ascorbic,Acid, L-Ascorbic,Ascorbate, Ferrous,Ascorbate, Magnesium,Ascorbate, Sodium,L Ascorbic Acid,Magnesium di L Ascorbate,di-L-Ascorbate, Magnesium
D012513 Sarcoma, Experimental Experimentally induced neoplasms of CONNECTIVE TISSUE in animals to provide a model for studying human SARCOMA. EHS Tumor,Sarcoma, Engelbreth-Holm-Swarm,Sarcoma, Jensen,Experimental Sarcoma,Experimental Sarcomas,Sarcomas, Experimental,Engelbreth-Holm-Swarm Sarcoma,Jensen Sarcoma,Sarcoma, Engelbreth Holm Swarm,Tumor, EHS

Related Publications

V S Turusov, and L S Trukhanova, and Parfenov YuD
[Modifying effect of ascorbic acid and sodium ascorbate on uterine carcomogenesis induced by 1,2-dimethylhydrazine in CBA mice].
January 1988, Eksperimental'naia onkologiia,
V S Turusov, and L S Trukhanova, and Parfenov YuD
[Effects of cortiphen and cyclophosphamide in uterine sarcoma induced primarily by 1,2-dimethylhydrazine and estradiol dipropionate in CBA mice].
January 1990, Eksperimental'naia onkologiia,
V S Turusov, and L S Trukhanova, and Parfenov YuD
[Stimulating action of estradiol dipropionate on uterine sarcomagenesis induced by 1,2-dimethylhydrazine in mice].
November 1980, Biulleten' eksperimental'noi biologii i meditsiny,
V S Turusov, and L S Trukhanova, and Parfenov YuD
[Proliferative activity of the uterine epithelium and mesenchymal elements in CBA-strain mice administered 1,2-dimethylhydrazine and estradiol dipropionate].
January 1986, Eksperimental'naia onkologiia,
V S Turusov, and L S Trukhanova, and Parfenov YuD
Non-epithelial uterine tumours induced in CBA mice by 1,2-dimethylhydrazine.
July 1977, Cancer letters,
V S Turusov, and L S Trukhanova, and Parfenov YuD
[Effect of neonatal androgenization on uterine sarcomagenesis induced by 1,2-dimethylhydrazine in female CBA mice].
October 1983, Biulleten' eksperimental'noi biologii i meditsiny,
V S Turusov, and L S Trukhanova, and Parfenov YuD
[Transplantation of 1,2-dimethylhydrazine-induced uterine sarcomas in CBA mice].
January 1978, Voprosy onkologii,
V S Turusov, and L S Trukhanova, and Parfenov YuD
[Modifying action of neonatal androgenization on 1,2-dimethylhydrazine-induced carcinogenesis in male CBA-strain mice].
February 1985, Biulleten' eksperimental'noi biologii i meditsiny,
V S Turusov, and L S Trukhanova, and Parfenov YuD
[Effect of age, castration and pregnancy on carcinogenesis, induced by 1,2-dimethylhydrazine, in CBA mice].
May 1979, Biulleten' eksperimental'noi biologii i meditsiny,
V S Turusov, and L S Trukhanova, and Parfenov YuD
Renal cell tumors induced in CBA male mice by 1,2-dimethylhydrazine.
January 1992, Toxicologic pathology,
Copied contents to your clipboard!