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Analysis of whole-arm translocations in malignant blood cells by nonisotopic in situ hybridization. 1991
F Speleman, and
K Mangelschots, and
M Vercruyssen, and
P Dal Cin, and
A Aventin, and
F Offner, and
G Laureys, and
H Van den Berghe, and
J Leroy
Department of Medical Genetics, University Hospital, Ghent, Belgium.
Whole-arm translocations in five leukemic patients were studied using nonisotopic in situ hybridization with alpha satellite DNA and simple satellite chromosome-specific DNA probes to detect the target sequences. The results show that this technique provides additional information on the involvement of these DNA sequences in whole-arm translocations.
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