Preservation methods for kidney and liver. 2009

Charles Y Lee, and Martin J Mangino
Department of Mechanical Engineering and Engineering Science; University of North Carolina; Charlotte, NC USA.

With the successful testing of the immunosuppressive effects of cyclosporine in transplant patients in 1978, the field of organ transplants began an exponential growth. With that, the field of organ preservation became increasingly important as the need to increase preservation time and improve graft function became paramount. However, for every patient that receives a transplanted organ, there are four more on the waiting list. In addition, a patient dies from the lack of a transplant almost every 1(1/2) hour. To alleviate this donor crisis, there is a need to expand the donor pool to marginal donor organs. The main reason these organs are underutilized is because the current method of static preservation, simple cold storage, is ineffective. This article will provide a general review of the methods of preservation including simple cold storage, hypothermic machine perfusion, normothermic machine perfusion, and oxygen persufflation. In addition, the article will provide a review of how these dynamic preservation methods have improved the recovery and preservation of marginal donor organs including Donation after Cardiac Death and Fatty livers.

UI MeSH Term Description Entries

Related Publications

Charles Y Lee, and Martin J Mangino
October 1986, Boletin de la Asociacion Medica de Puerto Rico,
Charles Y Lee, and Martin J Mangino
January 1970, Acta chirurgica Belgica,
Charles Y Lee, and Martin J Mangino
January 1975, L'Ateneo parmense. Acta bio-medica : organo della Societa di medicina e scienze naturali di Parma,
Charles Y Lee, and Martin J Mangino
March 1973, Lancet (London, England),
Charles Y Lee, and Martin J Mangino
March 1973, Lancet (London, England),
Charles Y Lee, and Martin J Mangino
May 1973, Lancet (London, England),
Charles Y Lee, and Martin J Mangino
April 1973, Lancet (London, England),
Charles Y Lee, and Martin J Mangino
May 1978, The Journal of surgical research,
Charles Y Lee, and Martin J Mangino
November 1968, Minnesota medicine,
Charles Y Lee, and Martin J Mangino
February 2002, Lancet (London, England),
Copied contents to your clipboard!