Biomaterial Database

Hemin-binding property of Porphyromonas gingivalis outer membranes. 1991

D Grenier

Département de Santé Buccale, Faculté de Médecine Dentaire, Université de Montréal, Québec, Canada.

The present study indicates that the outer membranes of Porphyromonas gingivalis have a high affinity for hemin, an essential growth factor for this suspected periodontal pathogen. The hemin-binding property appears to be mediated by the lipopolysaccharides, particularly the lipid A region. It is suggested that this binding mechanism may be important for the growth and establishment of P. gingivalis in environments with a low hemin content such as periodontal pockets.

UI	MeSH Term	Description	Entries
D002462	Cell Membrane	The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.	Plasma Membrane,Cytoplasmic Membrane,Cell Membranes,Cytoplasmic Membranes,Membrane, Cell,Membrane, Cytoplasmic,Membrane, Plasma,Membranes, Cell,Membranes, Cytoplasmic,Membranes, Plasma,Plasma Membranes
D006133	Growth Substances	Signal molecules that are involved in the control of cell growth and differentiation.	Mitogens, Endogenous,Endogenous Mitogens
D006427	Hemin	Chloro(7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N(21),N(22),N(23),N(24)) ferrate(2-) dihydrogen.	Ferriprotoporphyrin,Hematin,Alkaline Hematin D-575,Chlorohemin,Ferrihaem,Ferriheme Chloride,Ferriprotoporphyrin IX,Ferriprotoporphyrin IX Chloride,Panhematin,Protohemin,Protohemin IX,Alkaline Hematin D 575,Chloride, Ferriheme,Chloride, Ferriprotoporphyrin IX,Hematin D-575, Alkaline
D001438	Bacteroidaceae	A family of gram-negative bacteria found primarily in the intestinal tracts and mucous membranes of warm-blooded animals. Its organisms are sometimes pathogenic.