OBJECTIVE To establish an ICP-MS method for the simultaneous determination of 15 rare earth elements (REEs) in Cosmetics. METHODS Cosmetics were digested with HNO3 + H2O2 by microwave oven. An interference-free isotope was chosen for earth REE as 89Y, 139 La, 140Ce, 141Pr, 146Nd, 147Sm, 153Eu, 157Gd, 159Tb, 163Dy, 165Ho, 166Er, 169Tm, 172Yb, 175Lu, 15 REEs were determined by ICP-MS. RESULTS The correlation coefficient r > or = 0.9998. The recovery rates and relative standard deviations could 89.3%-114.6% and 1.45%-7.93%. In the detection for real samples, La, Ce, Nd and Y were detected in creamy samples. 13 REEs in powdery samples, were detected except for Tm, Lu. Maybe their raw material source were different. CONCLUSIONS The results indicated that the method could be simple, rapid, sensitive and accurate, which could meet the demand of the simultaneous determination for 15 rare earth elements analysis in Cosmetics.