Ultrastructural changes in impotent penile tissue: a comparison of 65 patients. 1991

A Mersdorf, and P C Goldsmith, and W Diederichs, and C A Padula, and T F Lue, and I J Fishman, and E A Tanagho
Department of Urology, University of California School of Medicine, San Francisco.

To determine whether impotence is caused by specific and consistent changes in erectile tissue, we compared the ultrastructure of the corpora cavernosa in 6 controls with that in 59 patients undergoing implantation of a penile prosthesis. The impotent patients were divided into groups based on a medical history of hypertension (10), pelvic surgery (9), alcoholic smokers (8), hypertensive alcoholics (3), hypertensive alcoholic smokers (3), smokers (3), diabetics (8), diabetic smokers (3), Peyronie's disease (3), spinal cord injury (3) and isolated causes (6). Our data demonstrate that different behavioral and/or medical conditions produce similar degenerative tissue responses. There is no single or specific cause of impotence that is manifest by consistent changes in erectile tissue.

UI MeSH Term Description Entries
D006973 Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D007172 Erectile Dysfunction The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction. Impotence,Male Impotence,Male Sexual Impotence,Dysfunction, Erectile,Impotence, Male,Impotence, Male Sexual,Sexual Impotence, Male
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009474 Neurons The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM. Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D010411 Penile Induration A condition characterized by hardening of the PENIS due to the formation of fibrous plaques on the dorsolateral aspect of the PENIS, usually involving the membrane (tunica albuginea) surrounding the erectile tissue (corpus cavernosum penis). This may eventually cause a painful deformity of the shaft or constriction of the urethra, or both. Cavernitis, Fibrous,Peyronie's Disease,Penile Fibromatosis,Peyronie Disease,Plastic Induration of the Penis,Cavernitides, Fibrous,Fibromatosis, Penile,Fibrous Cavernitides,Fibrous Cavernitis,Peyronies Disease
D010413 Penis The external reproductive organ of males. It is composed of a mass of erectile tissue enclosed in three cylindrical fibrous compartments. Two of the three compartments, the corpus cavernosa, are placed side-by-side along the upper part of the organ. The third compartment below, the corpus spongiosum, houses the urethra. Glans Penis,Penis, Glans
D002196 Capillaries The minute vessels that connect arterioles and venules. Capillary Beds,Sinusoidal Beds,Sinusoids,Bed, Sinusoidal,Beds, Sinusoidal,Capillary,Capillary Bed,Sinusoid,Sinusoidal Bed
D003238 Connective Tissue Tissue that supports and binds other tissues. It consists of CONNECTIVE TISSUE CELLS embedded in a large amount of EXTRACELLULAR MATRIX. Connective Tissues,Tissue, Connective,Tissues, Connective
D004727 Endothelium A layer of epithelium that lines the heart, blood vessels (ENDOTHELIUM, VASCULAR), lymph vessels (ENDOTHELIUM, LYMPHATIC), and the serous cavities of the body. Endotheliums

Related Publications

A Mersdorf, and P C Goldsmith, and W Diederichs, and C A Padula, and T F Lue, and I J Fishman, and E A Tanagho
November 1993, British journal of urology,
A Mersdorf, and P C Goldsmith, and W Diederichs, and C A Padula, and T F Lue, and I J Fishman, and E A Tanagho
October 1975, The British journal of psychiatry : the journal of mental science,
A Mersdorf, and P C Goldsmith, and W Diederichs, and C A Padula, and T F Lue, and I J Fishman, and E A Tanagho
August 2009, The journal of sexual medicine,
A Mersdorf, and P C Goldsmith, and W Diederichs, and C A Padula, and T F Lue, and I J Fishman, and E A Tanagho
October 1985, Urology,
A Mersdorf, and P C Goldsmith, and W Diederichs, and C A Padula, and T F Lue, and I J Fishman, and E A Tanagho
January 1987, Progress in neuro-psychopharmacology & biological psychiatry,
A Mersdorf, and P C Goldsmith, and W Diederichs, and C A Padula, and T F Lue, and I J Fishman, and E A Tanagho
January 1997, Abdominal imaging,
A Mersdorf, and P C Goldsmith, and W Diederichs, and C A Padula, and T F Lue, and I J Fishman, and E A Tanagho
March 1980, Southern medical journal,
A Mersdorf, and P C Goldsmith, and W Diederichs, and C A Padula, and T F Lue, and I J Fishman, and E A Tanagho
February 1975, Urology,
A Mersdorf, and P C Goldsmith, and W Diederichs, and C A Padula, and T F Lue, and I J Fishman, and E A Tanagho
January 2005, International journal of impotence research,
A Mersdorf, and P C Goldsmith, and W Diederichs, and C A Padula, and T F Lue, and I J Fishman, and E A Tanagho
January 1991, European urology,
Copied contents to your clipboard!