BIOMAT Database Logo BIOMAT Database Logo

Hypoglycemic effects of Cecropia pachystachya in normal and alloxan-induced diabetic rats. 2010

Danielle M O Aragão, and Lyvia Guarize, and Juliana Lanini, and Juliana C da Costa, and Raúl M G Garcia, and Elita Scio
Departamento de Bioquímica - ICB - Universidade Federal de Juiz de Fora, Campus Universitário, Martelos, CEP 36036 900, Juiz de Fora, MG, Brazil.

BACKGROUND Leaves of Cecropia pachystachya are described in the folk medicine as possessing antitusive, expectorant, antiasthmatic and hypoglycemic effects. OBJECTIVE To investigate the hypoglycemic and antioxidant effects of methanolic extract from the leaves of Cecropia pachystachya. The total amount of phenolic and flavonoids compounds was determined and the qualitative composition of the extract was analyzed. METHODS The hypoglycemic effect of the extract was tested in normal, glucose loading and alloxan-induced diabetic rats. The antioxidant activity was assessed by DPPH free radical scavenging and reduction power assays. The total amount of phenolic and flavonoids compounds was determined by Folin-Denis and AlCl(3) reagent method, respectively. The qualitative composition of the extract was analyzed using a HPLC-DAD system. RESULTS The glucose tolerance test showed that in diabetic rats, the extract caused a significant hypoglycemic effect with a blood glucose reduction of 68% after 12h. The administration of the extract in alloxan-induced diabetic rats also produced a significant reduction in the blood glucose levels at all points being more pronounced at 90min (reduction of 60%). After 120min, no significant difference was observed between the blood levels of the rats treated with the extract and those treated with the standard drugs (metformin and glibenclamide). The extract also presented relevant antioxidant activity with IC50=3.1microg/ml (DPPH assay) and EC50=10.8microg/ml (reduction power). Results were compared with the reference antioxidants quercetin, rutin, and ascorbic acid. The content of flavonoids was 83mg/g plant and that of phenolics was 326mg/g plant. Chlorogenic acid and the C-glycosylated flavones, orientin and isoorientin, were identified in the extract. CONCLUSIONS In conclusion, the findings showed that the folk medicinal plant Cecropia pachystachya possesses hypoglycemic and antioxidant effects which confirmed the traditional use of the plant in the treatment of diabetes. Chlorogenic acid and the C-glycosylated flavonoids may explain these activities.

UI MeSH Term Description Entries
D007004 Hypoglycemic Agents Substances which lower blood glucose levels. Antidiabetic,Antidiabetic Agent,Antidiabetic Drug,Antidiabetics,Antihyperglycemic,Antihyperglycemic Agent,Hypoglycemic,Hypoglycemic Agent,Hypoglycemic Drug,Antidiabetic Agents,Antidiabetic Drugs,Antihyperglycemic Agents,Antihyperglycemics,Hypoglycemic Drugs,Hypoglycemic Effect,Hypoglycemic Effects,Hypoglycemics,Agent, Antidiabetic,Agent, Antihyperglycemic,Agent, Hypoglycemic,Agents, Antidiabetic,Agents, Antihyperglycemic,Agents, Hypoglycemic,Drug, Antidiabetic,Drug, Hypoglycemic,Drugs, Antidiabetic,Drugs, Hypoglycemic,Effect, Hypoglycemic,Effects, Hypoglycemic
D008297 Male Males
D008519 Medicine, Traditional Systems of medicine based on cultural beliefs and practices handed down from generation to generation. The concept includes mystical and magical rituals (SPIRITUAL THERAPIES); PHYTOTHERAPY; and other treatments which may not be explained by modern medicine. Ethnomedicine,Folk Medicine,Folk Remedies,Home Remedies,Medicine, Folk,Medicine, Indigenous,Medicine, Primitive,Indigenous Medicine,Primitive Medicine,Traditional Medicine,Folk Remedy,Home Remedy,Remedies, Folk,Remedies, Home,Remedy, Folk,Remedy, Home
D008687 Metformin A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289) Dimethylguanylguanidine,Dimethylbiguanidine,Glucophage,Metformin HCl,Metformin Hydrochloride,HCl, Metformin,Hydrochloride, Metformin
D010636 Phenols Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.
D010936 Plant Extracts Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard. Herbal Medicines,Plant Extract,Extract, Plant,Extracts, Plant,Medicines, Herbal
D001786 Blood Glucose Glucose in blood. Blood Sugar,Glucose, Blood,Sugar, Blood
D003920 Diabetes Mellitus A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
D003924 Diabetes Mellitus, Type 2 A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY. Diabetes Mellitus, Adult-Onset,Diabetes Mellitus, Ketosis-Resistant,Diabetes Mellitus, Maturity-Onset,Diabetes Mellitus, Non-Insulin-Dependent,Diabetes Mellitus, Slow-Onset,Diabetes Mellitus, Stable,MODY,Maturity-Onset Diabetes Mellitus,NIDDM,Diabetes Mellitus, Non Insulin Dependent,Diabetes Mellitus, Noninsulin Dependent,Diabetes Mellitus, Noninsulin-Dependent,Diabetes Mellitus, Type II,Maturity-Onset Diabetes,Noninsulin-Dependent Diabetes Mellitus,Type 2 Diabetes,Type 2 Diabetes Mellitus,Adult-Onset Diabetes Mellitus,Diabetes Mellitus, Adult Onset,Diabetes Mellitus, Ketosis Resistant,Diabetes Mellitus, Maturity Onset,Diabetes Mellitus, Slow Onset,Diabetes, Maturity-Onset,Diabetes, Type 2,Ketosis-Resistant Diabetes Mellitus,Maturity Onset Diabetes,Maturity Onset Diabetes Mellitus,Non-Insulin-Dependent Diabetes Mellitus,Noninsulin Dependent Diabetes Mellitus,Slow-Onset Diabetes Mellitus,Stable Diabetes Mellitus
D005419 Flavonoids A group of phenyl benzopyrans named for having structures like FLAVONES. 2-Phenyl-Benzopyran,2-Phenyl-Chromene,Bioflavonoid,Bioflavonoids,Flavonoid,2-Phenyl-Benzopyrans,2-Phenyl-Chromenes,2 Phenyl Benzopyran,2 Phenyl Benzopyrans,2 Phenyl Chromene,2 Phenyl Chromenes

Related Publications

Danielle M O Aragão, and Lyvia Guarize, and Juliana Lanini, and Juliana C da Costa, and Raúl M G Garcia, and Elita Scio
Hypoglycemic and antiperglycemic effects of Semecarpus anacardium linn in normal and alloxan-induced diabetic rats.
January 2005, Journal of herbal pharmacotherapy,
Danielle M O Aragão, and Lyvia Guarize, and Juliana Lanini, and Juliana C da Costa, and Raúl M G Garcia, and Elita Scio
Hypoglycemic and hypolipidemic effects of aqueous extract of Arachis hypogaea in normal and alloxan-induced diabetic rats.
September 2002, Phytomedicine : international journal of phytotherapy and phytopharmacology,
Danielle M O Aragão, and Lyvia Guarize, and Juliana Lanini, and Juliana C da Costa, and Raúl M G Garcia, and Elita Scio
Antihyperglycemic and hypoglycemic effect of Aporosa lindleyana in normal and alloxan induced diabetic rats.
February 2003, Journal of ethnopharmacology,
Danielle M O Aragão, and Lyvia Guarize, and Juliana Lanini, and Juliana C da Costa, and Raúl M G Garcia, and Elita Scio
Hypoglycemic effects of Potentilla fulgens L in normal and alloxan-induced diabetic mice.
November 2002, Journal of ethnopharmacology,
Danielle M O Aragão, and Lyvia Guarize, and Juliana Lanini, and Juliana C da Costa, and Raúl M G Garcia, and Elita Scio
Hypoglycemic and other related effects of Boswellia glabra in alloxan-induced diabetic rats.
January 2007, Indian journal of physiology and pharmacology,
Danielle M O Aragão, and Lyvia Guarize, and Juliana Lanini, and Juliana C da Costa, and Raúl M G Garcia, and Elita Scio
Hypoglycemic, antilipidemic and antioxidant effects of valproic acid in alloxan-induced diabetic rats.
September 2015, European journal of pharmacology,
Danielle M O Aragão, and Lyvia Guarize, and Juliana Lanini, and Juliana C da Costa, and Raúl M G Garcia, and Elita Scio
Evaluation of hypoglycemic and antihyperglycemic effects of Datura metel (Linn.) seeds in normal and alloxan-induced diabetic rats.
March 2004, Journal of ethnopharmacology,
Danielle M O Aragão, and Lyvia Guarize, and Juliana Lanini, and Juliana C da Costa, and Raúl M G Garcia, and Elita Scio
Hypoglycemic effect of Gymnema sylvestre (retz.,) R.Br leaf in normal and alloxan induced diabetic rats.
October 2008, Ancient science of life,
Danielle M O Aragão, and Lyvia Guarize, and Juliana Lanini, and Juliana C da Costa, and Raúl M G Garcia, and Elita Scio
Hypoglycemic effect of Treculia africana Decne root bark in normal and alloxan-induced diabetic rats.
June 2007, African journal of traditional, complementary, and alternative medicines : AJTCAM,
Danielle M O Aragão, and Lyvia Guarize, and Juliana Lanini, and Juliana C da Costa, and Raúl M G Garcia, and Elita Scio
Hypoglycemic and antihyperglycemic effect of Gmelina asiatica LINN. in normal and in alloxan induced diabetic rats.
April 2005, Biological & pharmaceutical bulletin,
Copied contents to your clipboard!