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The retinal vessel filling time of 10 patients with early nonproliferative diabetic retinography was measured by fluorescein angiography. Initially, the reproducibility of the authors' standardized fluorescein angiography was assessed by control angiograms on two different dates in each patient. Thereafter, prolonged use (six months) of isoxsuprine sustained release (80 mg/day) led to a nearly 50% reduction of the arterial filling time and a nearly 25% reduction of the arteriovenous filling time, whereas no changes were seen in control patients. This effect of isoxsuprine might be explained by an increase of red cell deformability and, concomitantly, a decrease of platelet adherence in the microcirculation of patients with diabetic mellitus.
M R Dandrieu, and
M M Brood-van Zanten
June 2019,
JAMA ophthalmology,
M R Dandrieu, and
M M Brood-van Zanten
January 1965,
Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde,
M R Dandrieu, and
M M Brood-van Zanten
January 1965,
Transactions of the American Ophthalmological Society,
M R Dandrieu, and
M M Brood-van Zanten
June 1991,
Nippon Ganka Gakkai zasshi,
M R Dandrieu, and
M M Brood-van Zanten
September 1967,
Archives d'ophtalmologie et revue generale d'ophtalmologie,
M R Dandrieu, and
M M Brood-van Zanten
January 2003,
Oftalmologia (Bucharest, Romania : 1990),
M R Dandrieu, and
M M Brood-van Zanten
January 1988,
Retina (Philadelphia, Pa.),
M R Dandrieu, and
M M Brood-van Zanten
January 2017,
Ophthalmic research,
M R Dandrieu, and
M M Brood-van Zanten
June 1987,
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie,
M R Dandrieu, and
M M Brood-van Zanten
January 2013,
Clinical ophthalmology (Auckland, N.Z.),
