Biomaterial Database

Effects of feeding condition on orally delivered ethanol as a reinforcer for rhesus monkeys. 1991

R A Meisch, and G A Lemaire

Department of Psychiatry and Behavioral Sciences, U.T.M.S.I. University of Texas Health Science Center, Houston 77030-3406.

Twenty adult male rhesus monkeys could drink either or both an 8%-ethanol (w/v) solution or water during daily 3-h experimental sessions. Subjects were initially tested under ad lib feeding conditions, having received daily access to large amounts of food for approximately 8 months (Phase 1). The ethanol solution was concurrently available with its water vehicle under fixed-ratio schedules of mouth contacts with a drinking spout in which emission of 8 responses produced a liquid delivery (FR 8). Under these conditions ethanol served as a reinforcer for some subjects--it maintained higher response rates than water--but not for others. In the next experimental condition (Phase 2), subjects were again tested for ethanol self-administration under FR 8 schedules with water concurrently available, but while receiving daily food rations that maintained their body weights at less than what they had been under ad lib feeding conditions. Under these conditions all subjects self-administered ethanol at appreciable levels, but water-maintained responding also was at appreciable levels for some subjects. Increases in ethanol self-administration following institution of the reduced-feeding conditions in Phase 2 generally were inversely related to self-administration levels under the free-feeding conditions of Phase 1 (the greatest proportional increases in ethanol intake occurred with those monkeys that self-administered the least amount of ethanol in Phase 1). In Phase 3, the requirements of the concurrently operating fixed-ratio schedules delivering ethanol and water were increased to 16 responses (FR 16).(ABSTRACT TRUNCATED AT 250 WORDS)

UI	MeSH Term	Description	Entries
D008253	Macaca mulatta	A species of the genus MACACA inhabiting India, China, and other parts of Asia. The species is used extensively in biomedical research and adapts very well to living with humans.	Chinese Rhesus Macaques,Macaca mulatta lasiota,Monkey, Rhesus,Rhesus Monkey,Rhesus Macaque,Chinese Rhesus Macaque,Macaca mulatta lasiotas,Macaque, Rhesus,Rhesus Macaque, Chinese,Rhesus Macaques,Rhesus Macaques, Chinese,Rhesus Monkeys
D008297	Male		Males
D012054	Reinforcement, Psychology	The strengthening of a conditioned response.	Negative Reinforcement,Positive Reinforcement,Psychological Reinforcement,Reinforcement (Psychology),Negative Reinforcements,Positive Reinforcements,Psychological Reinforcements,Psychology Reinforcement,Psychology Reinforcements,Reinforcement, Negative,Reinforcement, Positive,Reinforcement, Psychological,Reinforcements (Psychology),Reinforcements, Negative,Reinforcements, Positive,Reinforcements, Psychological,Reinforcements, Psychology
D012055	Reinforcement Schedule	A schedule prescribing when the subject is to be reinforced or rewarded in terms of temporal interval in psychological experiments. The schedule may be continuous or intermittent.	Reinforcement Schedules,Schedule, Reinforcement,Schedules, Reinforcement
D005502	Food	Substances taken in by the body to provide nourishment.	Foods
D000284	Administration, Oral	The giving of drugs, chemicals, or other substances by mouth.	Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D000431	Ethanol	A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.	Alcohol, Ethyl,Absolute Alcohol,Grain Alcohol,Alcohol, Absolute,Alcohol, Grain,Ethyl Alcohol
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012646	Self Administration	Administration of a drug or chemical by the individual under the direction of a physician. It includes administration clinically or experimentally, by human or animal.	Administration, Self,Administrations, Self,Self Administrations