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Evaluation of the retinal nerve fiber layer measurements, after photorefractive keratectomy and laser in situ keratomileusis, using scanning laser polarimetry (GDX VCC). 2010

Antonios P Aristeidou, and Georgios Labiris, and Eleftherios I Paschalis, and Nikitas C Foudoulakis, and Stavrenia C Koukoula, and Vassilios P Kozobolis
Department of Ophthalmology & Eye Institute of Thrace, Democritus University of Thrace, Alexandroupolis, Greece. aaristeidou@yahoo.gr

BACKGROUND To evaluate the impact of photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK), on retinal nerve fiber layer (RNFL) measurements, by means of scanning laser polarimetry (SLP) GDx VCC (with variable corneal compensation). METHODS Two groups of 119 myopic patients each were treated by PRK and LASIK respectively; one eye of each patient was randomly selected for the study. RNFL measurements (around the entire calculation circle) was performed in all eyes 1 day before and 1, 3, 6 and 12 months after treatment by using SLP GDx VCC. Corneal compensation was performed in all eyes preoperatively, and in every examination step postoperatively, in order to neutralize the new corneal birefringence. RESULTS No statistical differences were found between the PRK and LASIK groups, in all preoperative and postoperative RNFL measurements. Only the p values for CCT and mean K-readings preoperatively were statistically significant. CONCLUSIONS PRK and LASIK do not seem to influence the RNFL measurements at 1st, 3rd, 6th and 12th postoperative months when measured with SLP GDx VCC. The corneal compensation reset is necessary in every step of the examination in order to have reproducible results.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009216 Myopia A refractive error in which rays of light entering the EYE parallel to the optic axis are brought to a focus in front of the RETINA when accommodation (ACCOMMODATION, OCULAR) is relaxed. This results from an overly curved CORNEA or from the eyeball being too long from front to back. It is also called nearsightedness. Nearsightedness,Myopias,Nearsightednesses
D009412 Nerve Fibers Slender processes of NEURONS, including the AXONS and their glial envelopes (MYELIN SHEATH). Nerve fibers conduct nerve impulses to and from the CENTRAL NERVOUS SYSTEM. Cerebellar Mossy Fibers,Mossy Fibers, Cerebellar,Cerebellar Mossy Fiber,Mossy Fiber, Cerebellar,Nerve Fiber
D011184 Postoperative Period The period following a surgical operation. Period, Postoperative,Periods, Postoperative,Postoperative Periods
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D003315 Cornea The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous CORNEAL EPITHELIUM; BOWMAN MEMBRANE; CORNEAL STROMA; DESCEMET MEMBRANE; and mesenchymal CORNEAL ENDOTHELIUM. It serves as the first refracting medium of the eye. It is structurally continuous with the SCLERA, avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the TRIGEMINAL NERVE via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed) Corneas
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths

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