BIOMAT Database Logo BIOMAT Database Logo

Versatile roles for myosin Va in dense core vesicle biogenesis and function. 2010

Tanja Kögel, and Claudia Margarethe Bittins, and Rüdiger Rudolf, and Hans-Hermann Gerdes
Department of Biomedicine, University of Bergen, Jonas Lies Vei 91, 5009 Bergen, Norway.

The motor protein myosin Va is involved in multiple successive steps in the development of dense-core vesicles, such as in the membrane remodelling during their maturation, their transport along actin filaments and the regulation of their exocytosis. In the present paper, we summarize the current knowledge on the roles of myosin Va in the different steps of dense-core vesicle biogenesis and exocytosis, and compare findings obtained from different cell types and experimental systems.

UI MeSH Term Description Entries
D009474 Neurons The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM. Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D005089 Exocytosis Cellular release of material within membrane-limited vesicles by fusion of the vesicles with the CELL MEMBRANE.
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D050417 Insulin-Secreting Cells A type of pancreatic cell representing about 50-80% of the islet cells. Beta cells secrete INSULIN. Pancreatic beta Cells,beta Cells, Pancreatic,Pancreatic B Cells,B Cell, Pancreatic,B Cells, Pancreatic,Cell, Insulin-Secreting,Cells, Insulin-Secreting,Insulin Secreting Cells,Insulin-Secreting Cell,Pancreatic B Cell,Pancreatic beta Cell,beta Cell, Pancreatic
D019439 Chromaffin Cells Cells that store epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia (PARAGANGLIA, CHROMAFFIN) of the sympathetic nervous system. Cell, Chromaffin,Cells, Chromaffin,Chromaffin Cell
D022142 Secretory Vesicles Vesicles derived from the GOLGI APPARATUS containing material to be released at the cell surface. SLMVs,Secretory Granules,Synaptic Like Microvesicles,Synaptic-Like Microvesicles,Zymogen Granules,Condensing Vacuoles,Condensing Vacuole,Granule, Secretory,Granule, Zymogen,Microvesicle, Synaptic-Like,Secretory Granule,Secretory Vesicle,Synaptic Like Microvesicle,Synaptic-Like Microvesicle,Vacuole, Condensing,Vesicle, Secretory,Zymogen Granule
D024701 Myosin Type V A subclass of myosin involved in organelle transport and membrane targeting. It is abundantly found in nervous tissue and neurosecretory cells. The heavy chains of myosin V contain unusually long neck domains that are believed to aid in translocating molecules over large distances. Myosin V,Myosin-V p190,Myosin V p190

Related Publications

Tanja Kögel, and Claudia Margarethe Bittins, and Rüdiger Rudolf, and Hans-Hermann Gerdes
Role of clathrin in dense core vesicle biogenesis.
October 2017, Molecular biology of the cell,
Tanja Kögel, and Claudia Margarethe Bittins, and Rüdiger Rudolf, and Hans-Hermann Gerdes
The SNARE protein vti1a functions in dense-core vesicle biogenesis.
August 2014, The EMBO journal,
Tanja Kögel, and Claudia Margarethe Bittins, and Rüdiger Rudolf, and Hans-Hermann Gerdes
Molecular mechanism of myosin Va recruitment to dense core secretory granules.
January 2012, Traffic (Copenhagen, Denmark),
Tanja Kögel, and Claudia Margarethe Bittins, and Rüdiger Rudolf, and Hans-Hermann Gerdes
Myosin Va transports dense core secretory vesicles in pancreatic MIN6 beta-cells.
June 2005, Molecular biology of the cell,
Tanja Kögel, and Claudia Margarethe Bittins, and Rüdiger Rudolf, and Hans-Hermann Gerdes
Dense-core vesicle biogenesis and exocytosis in neurons lacking chromogranins A and B.
February 2018, Journal of neurochemistry,
Tanja Kögel, and Claudia Margarethe Bittins, and Rüdiger Rudolf, and Hans-Hermann Gerdes
Dense-core secretory granule biogenesis.
April 2006, Physiology (Bethesda, Md.),
Tanja Kögel, and Claudia Margarethe Bittins, and Rüdiger Rudolf, and Hans-Hermann Gerdes
Roles for myosin Va in RNA transport and turnover.
December 2012, Biochemical Society transactions,
Tanja Kögel, and Claudia Margarethe Bittins, and Rüdiger Rudolf, and Hans-Hermann Gerdes
Identification of the functional domain of the dense core vesicle biogenesis factor HID-1.
January 2023, PloS one,
Tanja Kögel, and Claudia Margarethe Bittins, and Rüdiger Rudolf, and Hans-Hermann Gerdes
Synaptotagmin function in dense core vesicle exocytosis studied in cracked PC12 cells.
July 2002, Nature neuroscience,
Tanja Kögel, and Claudia Margarethe Bittins, and Rüdiger Rudolf, and Hans-Hermann Gerdes
Dominant-negative myosin Va impairs retrograde but not anterograde axonal transport of large dense core vesicles.
April 2010, Cellular and molecular neurobiology,
Copied contents to your clipboard!