BIOMAT Database Logo BIOMAT Database Logo

Exhaled nitric oxide and nitric oxide synthase expression in Hodgkin's disease. 2009

G Guida, and B Culla, and T Scirelli, and G Bellone, and S Sciascia, and L Brussino, and D Novero, and G Palestro, and E Heffler, and P Gavarotti, and G Rolla, and C Bucca
Department of Biomedical Sciences and Human Oncology, University of Torino, Torino, Italy.

Hodgkin's disease (HD) is a malignant lymphoma with frequent mediastinal involvement, characterized by a significant inflammatory infiltration. Exhaled nitric oxide (FENO), is present in healthy humans, and has been proven to be increased in eosinophilic diseases such as allergic asthma. We investigated whether FENO is increased in mediastinal HD and whether NO is produced by lymphoma tissue. To this aim FENO was measured in 56 HD patients, 17 with and 39 without bulky mediastinal involvement, in the period from January 2007 to December 2008. Thirty-seven patients were reassessed after remission. Lymph node biopsies of 10 patients were evaluated for inducible (iNOS) and constitutive (eNOS) nitric oxide synthase expression by immunohistochemistry. FENO resulted significantly related to the mediastinal mass maximum diameter (p=0.009) and was significantly higher in patients with as compared to those without bulky mediastinal disease (38.7 ppb, CI 95% 19.3-58.0, versus 20.7 ppb, CI 95% 16.6-24.7; p=0.009). iNOS and eNOS immunoreactivity was observed in tumour and inflammatory cells (eosinophils and histiocytes). Only in patients with bulky mediastinal HD there was a significant decrease in FENO (from 50.4 ppb CI 95% 18.0-82.8 to 11.1 ppb CI 95% 4.4-17.8, p=0.011). In conclusion, high FENO and NOS expression in lymph-nodes indicate that NO is a component of the inflammatory network of HD. FENO may be proposed for the assessment and follow up of bulky mediastinal HD patients.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D008198 Lymph Nodes They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system. Lymph Node,Node, Lymph,Nodes, Lymph
D008297 Male Males
D008479 Mediastinal Neoplasms Tumors or cancer of the MEDIASTINUM. Cancer of Mediastinum,Mediastinal Cancer,Cancer of the Mediastinum,Mediastinum Cancer,Mediastinum Neoplasms,Neoplasms, Mediastinal,Cancer, Mediastinal,Cancer, Mediastinum,Cancers, Mediastinal,Cancers, Mediastinum,Mediastinal Cancers,Mediastinal Neoplasm,Mediastinum Cancers,Mediastinum Neoplasm,Neoplasm, Mediastinal,Neoplasm, Mediastinum,Neoplasms, Mediastinum
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009367 Neoplasm Staging Methods which attempt to express in replicable terms the extent of the neoplasm in the patient. Cancer Staging,Staging, Neoplasm,Tumor Staging,TNM Classification,TNM Staging,TNM Staging System,Classification, TNM,Classifications, TNM,Staging System, TNM,Staging Systems, TNM,Staging, Cancer,Staging, TNM,Staging, Tumor,System, TNM Staging,Systems, TNM Staging,TNM Classifications,TNM Staging Systems
D009569 Nitric Oxide A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP. Endogenous Nitrate Vasodilator,Mononitrogen Monoxide,Nitric Oxide, Endothelium-Derived,Nitrogen Monoxide,Endothelium-Derived Nitric Oxide,Monoxide, Mononitrogen,Monoxide, Nitrogen,Nitrate Vasodilator, Endogenous,Nitric Oxide, Endothelium Derived,Oxide, Nitric,Vasodilator, Endogenous Nitrate
D001944 Breath Tests Any tests done on exhaled air. Breathalyzer Tests,Breath Test,Breathalyzer Test,Test, Breath,Test, Breathalyzer,Tests, Breath,Tests, Breathalyzer
D005260 Female Females
D006689 Hodgkin Disease A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen. Granuloma, Hodgkin,Granuloma, Malignant,Hodgkin Lymphoma,Lymphogranuloma, Malignant,Granuloma, Hodgkin's,Granuloma, Hodgkins,Hodgkin Lymphoma, Adult,Hodgkin's Disease,Hodgkin's Lymphoma,Hodgkins Disease,Lymphocyte Depletion Hodgkin's Lymphoma,Lymphocyte-Rich Classical Hodgkin's Lymphoma,Mixed Cellularity Hodgkin's Lymphoma,Nodular Lymphocyte-Predominant Hodgkin's Lymphoma,Nodular Sclerosing Hodgkin's Lymphoma,Adult Hodgkin Lymphoma,Disease, Hodgkin,Disease, Hodgkin's,Disease, Hodgkins,Hodgkin Granuloma,Hodgkin's Granuloma,Hodgkins Granuloma,Hodgkins Lymphoma,Lymphocyte Rich Classical Hodgkin's Lymphoma,Lymphogranulomas, Malignant,Lymphoma, Hodgkin,Lymphoma, Hodgkin's,Malignant Granuloma,Malignant Granulomas,Malignant Lymphogranuloma,Malignant Lymphogranulomas,Nodular Lymphocyte Predominant Hodgkin's Lymphoma

Related Publications

G Guida, and B Culla, and T Scirelli, and G Bellone, and S Sciascia, and L Brussino, and D Novero, and G Palestro, and E Heffler, and P Gavarotti, and G Rolla, and C Bucca
Exhaled nitric oxide production by nitric oxide synthase-deficient mice.
October 2000, American journal of respiratory and critical care medicine,
G Guida, and B Culla, and T Scirelli, and G Bellone, and S Sciascia, and L Brussino, and D Novero, and G Palestro, and E Heffler, and P Gavarotti, and G Rolla, and C Bucca
Exhaled nitric oxide and inducible nitric oxide synthase gene polymorphism in Japanese asthmatics.
July 2016, Allergology international : official journal of the Japanese Society of Allergology,
G Guida, and B Culla, and T Scirelli, and G Bellone, and S Sciascia, and L Brussino, and D Novero, and G Palestro, and E Heffler, and P Gavarotti, and G Rolla, and C Bucca
Inducible nitric oxide synthase in the lung and exhaled nitric oxide after hyperoxia.
September 1999, The American journal of physiology,
G Guida, and B Culla, and T Scirelli, and G Bellone, and S Sciascia, and L Brussino, and D Novero, and G Palestro, and E Heffler, and P Gavarotti, and G Rolla, and C Bucca
Environmental exposures, nitric oxide synthase genes, and exhaled nitric oxide in asthmatic children.
August 2009, Pediatric pulmonology,
G Guida, and B Culla, and T Scirelli, and G Bellone, and S Sciascia, and L Brussino, and D Novero, and G Palestro, and E Heffler, and P Gavarotti, and G Rolla, and C Bucca
Exhaled nitric oxide is highly increased in a case of Hodgkin's disease.
January 2003, Acta oncologica (Stockholm, Sweden),
G Guida, and B Culla, and T Scirelli, and G Bellone, and S Sciascia, and L Brussino, and D Novero, and G Palestro, and E Heffler, and P Gavarotti, and G Rolla, and C Bucca
Fine Particulate Matter Constituents, Nitric Oxide Synthase DNA Methylation and Exhaled Nitric Oxide.
October 2015, Environmental science & technology,
G Guida, and B Culla, and T Scirelli, and G Bellone, and S Sciascia, and L Brussino, and D Novero, and G Palestro, and E Heffler, and P Gavarotti, and G Rolla, and C Bucca
Genetic variations in nitric oxide synthase and arginase influence exhaled nitric oxide levels in children.
March 2011, Allergy,
G Guida, and B Culla, and T Scirelli, and G Bellone, and S Sciascia, and L Brussino, and D Novero, and G Palestro, and E Heffler, and P Gavarotti, and G Rolla, and C Bucca
Nitric oxide levels in exhaled air and inducible nitric oxide synthase immunolocalization in pulmonary sarcoidosis.
October 1999, The European respiratory journal,
G Guida, and B Culla, and T Scirelli, and G Bellone, and S Sciascia, and L Brussino, and D Novero, and G Palestro, and E Heffler, and P Gavarotti, and G Rolla, and C Bucca
Effect of a nitric oxide synthase inhibitor and a glucocorticosteroid on exhaled nitric oxide.
September 1995, American journal of respiratory and critical care medicine,
G Guida, and B Culla, and T Scirelli, and G Bellone, and S Sciascia, and L Brussino, and D Novero, and G Palestro, and E Heffler, and P Gavarotti, and G Rolla, and C Bucca
Nitric oxide and nitric oxide synthase in Huntington's disease.
April 2001, Journal of neuroscience research,
Copied contents to your clipboard!