Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation. 2010

Matthew R Hayes, and Karolina P Skibicka, and Theresa M Leichner, and Douglas J Guarnieri, and Ralph J DiLeone, and Kendra K Bence, and Harvey J Grill
University of Pennsylvania, Philadelphia, 19104, USA. hayesmr@sas.upenn.edu

Medial nucleus tractus solitarius (mNTS) neurons express leptin receptors (LepRs), and intra-mNTS delivery of leptin reduces food intake and body weight. Here, the contribution of endogenous LepR signaling in mNTS neurons to energy balance control was examined. Knockdown of LepR in mNTS and area postrema (AP) neurons of rats (LepRKD) via adeno-associated virus short hairpin RNA-interference (AAV-shRNAi) resulted in significant hyperphagia for chow, high-fat, and sucrose diets, yielding increased body weight and adiposity. The chronic hyperphagia of mNTS/AP LepRKD rats is likely mediated by a reduction in leptin potentiation of gastrointestinal satiation signaling, as LepRKD rats showed decreased sensitivity to the intake-reducing effects of cholecystokinin. LepRKD rats showed increased basal AMP-kinase activity in mNTS/AP micropunches, and pharmacological data suggest that this increase provides a likely mechanism for their chronic hyperphagia. Overall these findings demonstrate that LepRs in mNTS and AP neurons are required for normal energy balance control.

UI MeSH Term Description Entries
D008297 Male Males
D001835 Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. Body Weights,Weight, Body,Weights, Body
D004435 Eating The consumption of edible substances. Dietary Intake,Feed Intake,Food Intake,Macronutrient Intake,Micronutrient Intake,Nutrient Intake,Nutritional Intake,Ingestion,Dietary Intakes,Feed Intakes,Intake, Dietary,Intake, Feed,Intake, Food,Intake, Macronutrient,Intake, Micronutrient,Intake, Nutrient,Intake, Nutritional,Macronutrient Intakes,Micronutrient Intakes,Nutrient Intakes,Nutritional Intakes
D004734 Energy Metabolism The chemical reactions involved in the production and utilization of various forms of energy in cells. Bioenergetics,Energy Expenditure,Bioenergetic,Energy Expenditures,Energy Metabolisms,Expenditure, Energy,Expenditures, Energy,Metabolism, Energy,Metabolisms, Energy
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D015398 Signal Transduction The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway. Cell Signaling,Receptor-Mediated Signal Transduction,Signal Pathways,Receptor Mediated Signal Transduction,Signal Transduction Pathways,Signal Transduction Systems,Pathway, Signal,Pathway, Signal Transduction,Pathways, Signal,Pathways, Signal Transduction,Receptor-Mediated Signal Transductions,Signal Pathway,Signal Transduction Pathway,Signal Transduction System,Signal Transduction, Receptor-Mediated,Signal Transductions,Signal Transductions, Receptor-Mediated,System, Signal Transduction,Systems, Signal Transduction,Transduction, Signal,Transductions, Signal
D017207 Rats, Sprague-Dawley A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company. Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats
D017552 Solitary Nucleus GRAY MATTER located in the dorsomedial part of the MEDULLA OBLONGATA associated with the solitary tract. The solitary nucleus receives inputs from most organ systems including the terminations of the facial, glossopharyngeal, and vagus nerves. It is a major coordinator of AUTONOMIC NERVOUS SYSTEM regulation of cardiovascular, respiratory, gustatory, gastrointestinal, and chemoreceptive aspects of HOMEOSTASIS. The solitary nucleus is also notable for the large number of NEUROTRANSMITTERS which are found therein. Nucleus Solitarius,Nuclei Tractus Solitarii,Nucleus Tractus Solitarii,Nucleus of Solitary Tract,Nucleus of Tractus Solitarius,Nucleus of the Solitary Tract,Solitary Nuclear Complex,Solitary Tract Nucleus,Complex, Solitary Nuclear,Complices, Solitary Nuclear,Nuclear Complex, Solitary,Nuclear Complices, Solitary,Nuclei Tractus Solitarius,Nucleus Tractus Solitarius,Nucleus, Solitary,Nucleus, Solitary Tract,Solitarii, Nuclei Tractus,Solitarius Nucleus, Tractus,Solitarius, Nuclei Tractus,Solitary Nuclear Complices,Tractus Solitarii, Nuclei,Tractus Solitarius Nucleus,Tractus Solitarius, Nuclei
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D054411 Receptors, Leptin Cell surface receptors for obesity factor (LEPTIN), a hormone secreted by the WHITE ADIPOCYTES. Upon leptin-receptor interaction, the signal is mediated through the JAK2/STAT3 pathway to regulate food intake, energy balance and fat storage. Antigens, CD295,CD295 Antigens,Leptin Receptors,OB Receptor,LEPR Protein,Leptin Receptor,Leptin Receptor, Large Isoform,Leptin Receptor, Small Isoform,Leptin-Binding Protein,OBRa Receptor,OBRb Receptor,Receptor, Leptin,Leptin Binding Protein,Receptor, OB,Receptor, OBRa,Receptor, OBRb

Related Publications

Matthew R Hayes, and Karolina P Skibicka, and Theresa M Leichner, and Douglas J Guarnieri, and Ralph J DiLeone, and Kendra K Bence, and Harvey J Grill
October 2008, Neurochemical research,
Matthew R Hayes, and Karolina P Skibicka, and Theresa M Leichner, and Douglas J Guarnieri, and Ralph J DiLeone, and Kendra K Bence, and Harvey J Grill
May 1991, The American journal of physiology,
Matthew R Hayes, and Karolina P Skibicka, and Theresa M Leichner, and Douglas J Guarnieri, and Ralph J DiLeone, and Kendra K Bence, and Harvey J Grill
June 1996, Brain research,
Matthew R Hayes, and Karolina P Skibicka, and Theresa M Leichner, and Douglas J Guarnieri, and Ralph J DiLeone, and Kendra K Bence, and Harvey J Grill
June 2017, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
Matthew R Hayes, and Karolina P Skibicka, and Theresa M Leichner, and Douglas J Guarnieri, and Ralph J DiLeone, and Kendra K Bence, and Harvey J Grill
August 2018, Psychopharmacology,
Matthew R Hayes, and Karolina P Skibicka, and Theresa M Leichner, and Douglas J Guarnieri, and Ralph J DiLeone, and Kendra K Bence, and Harvey J Grill
January 1993, Brain research bulletin,
Matthew R Hayes, and Karolina P Skibicka, and Theresa M Leichner, and Douglas J Guarnieri, and Ralph J DiLeone, and Kendra K Bence, and Harvey J Grill
October 1998, The American journal of physiology,
Matthew R Hayes, and Karolina P Skibicka, and Theresa M Leichner, and Douglas J Guarnieri, and Ralph J DiLeone, and Kendra K Bence, and Harvey J Grill
May 1993, The American journal of physiology,
Matthew R Hayes, and Karolina P Skibicka, and Theresa M Leichner, and Douglas J Guarnieri, and Ralph J DiLeone, and Kendra K Bence, and Harvey J Grill
August 2012, American journal of physiology. Endocrinology and metabolism,
Matthew R Hayes, and Karolina P Skibicka, and Theresa M Leichner, and Douglas J Guarnieri, and Ralph J DiLeone, and Kendra K Bence, and Harvey J Grill
January 1993, Brain research bulletin,
Copied contents to your clipboard!