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This study evaluates the effect of dietary magnesium concentration on calcium metabolism in rats of differing ages. Young (3 wk) and old (18 mo) Fischer 344 rats were fed the AIN-76A diet modified to contain either low (218 mg/kg) or adequate (419 mg/kg) Mg for 4 wk. Some rats subsequently underwent a metabolic balance study (12 d duration). Other rats were gavaged with approximately 220 KBq (6 microCi) of 47Ca; daily fecal and urine collections were made and periodic whole body radioactivity determined. Femurs were removed and analyzed. Calcium retention and balance were not affected by Mg in young rats. In old rats low Mg intake increased apparent Ca balance. Young rats retained about 3.25 times more of the original dose of 47Ca than did old rats. Young rats retained more 47Ca in the femur than did old rats; Mg intake had little effect. Aging accelerated Ca turnover rate, and whole body retention data suggest that adequate Mg does not significantly reduce Ca turnover.
S T McElroy, and
J E Link, and
R P Dowdy, and
K R Zinn, and
M R Ellersieck
December 1968,
American journal of veterinary research,
S T McElroy, and
J E Link, and
R P Dowdy, and
K R Zinn, and
M R Ellersieck
January 1968,
American journal of veterinary research,
S T McElroy, and
J E Link, and
R P Dowdy, and
K R Zinn, and
M R Ellersieck
January 1976,
International pharmacopsychiatry,
S T McElroy, and
J E Link, and
R P Dowdy, and
K R Zinn, and
M R Ellersieck
April 1974,
Acta endocrinologica,
S T McElroy, and
J E Link, and
R P Dowdy, and
K R Zinn, and
M R Ellersieck
March 1970,
The Journal of pharmacology and experimental therapeutics,
S T McElroy, and
J E Link, and
R P Dowdy, and
K R Zinn, and
M R Ellersieck
December 1969,
Endocrinology,
S T McElroy, and
J E Link, and
R P Dowdy, and
K R Zinn, and
M R Ellersieck
January 1970,
Journal de physiologie,
S T McElroy, and
J E Link, and
R P Dowdy, and
K R Zinn, and
M R Ellersieck
June 1920,
The Journal of experimental medicine,
S T McElroy, and
J E Link, and
R P Dowdy, and
K R Zinn, and
M R Ellersieck
November 1969,
The Journal of nutrition,
S T McElroy, and
J E Link, and
R P Dowdy, and
K R Zinn, and
M R Ellersieck
November 1959,
Nuclear-Medizin,
