Biomaterial Database

Leptin-sensitive neurons in mouse preoptic area express alpha 1A- and alpha 2A-adrenergic receptor isoforms. 2010

Andrea Frontini, and Antonio Giordano

Department of Molecular Pathology and Innovative Therapies, School of Medicine, Marche Polytechnic University, Via Tronto 10/A, 60020 Ancona, Italy.

Leptin binding to its functional receptor stimulates the Janus kinase-signal transducer and activator of transcription (JAK-STAT) signalling pathway, finally resulting in nuclear translocation of the phosphorylated STAT3 (P-STAT3). Systemic treatment with leptin (3mg/kg; intraperitoneal injection) induced the appearance of P-STAT3-immunoreactive cells in adult mouse preoptic area (POA). Here we show that the vast majority of leptin-responsive cells were located in medial POA (mPOA), followed by the median preoptic nucleus. Rare, scattered and weakly stained cells were found in ventromedial preoptic nucleus and lateral preoptic area. Co-localization studies disclosed that mPOA leptin-responsive cells were neurons, and that a large proportion expressed the alpha(1A)- and/or alpha(2A)-adrenergic receptor (AR) isoforms. Although understanding the functional relevance of leptin-responsive POA neurons requires further investigation, the finding that they bear alpha-ARs suggests that they may be targeted by the ascending noradrenergic system, which densely innervates the mPOA, and thus be involved in thermoregulation, arousal and/or the sleep-wake cycle.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009474	Neurons	The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.	Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D011301	Preoptic Area	Region of hypothalamus between the ANTERIOR COMMISSURE and OPTIC CHIASM.	Area Preoptica,Lateral Preoptic Area,Medial Preoptic Area,Preoptic Nuclei,Area Preopticas,Area, Lateral Preoptic,Area, Medial Preoptic,Area, Preoptic,Areas, Lateral Preoptic,Areas, Medial Preoptic,Areas, Preoptic,Lateral Preoptic Areas,Medial Preoptic Areas,Nuclei, Preoptic,Nucleus, Preoptic,Preoptic Area, Lateral,Preoptic Area, Medial,Preoptic Areas,Preoptic Areas, Lateral,Preoptic Areas, Medial,Preoptic Nucleus,Preoptica, Area,Preopticas, Area
D011994	Recombinant Proteins	Proteins prepared by recombinant DNA technology.	Biosynthetic Protein,Biosynthetic Proteins,DNA Recombinant Proteins,Recombinant Protein,Proteins, Biosynthetic,Proteins, Recombinant DNA,DNA Proteins, Recombinant,Protein, Biosynthetic,Protein, Recombinant,Proteins, DNA Recombinant,Proteins, Recombinant,Recombinant DNA Proteins,Recombinant Proteins, DNA
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D050796	STAT3 Transcription Factor	A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-6 family members. STAT3 is constitutively activated in a variety of TUMORS and is a major downstream transducer for the CYTOKINE RECEPTOR GP130.	APRF Transcription Factor,Acute-Phase Response Factor,IL6-Response Factor,LIF-Response Factor,STAT3 Protein,STAT3a Transcription Factor,STAT3b Transcription Factor,Signal Transducer and Activator of Transcription 3,Stat3alpha Transcription Factor,Stat3beta Transcription Factor,Acute Phase Response Factor,IL6 Response Factor,LIF Response Factor,Response Factor, Acute-Phase,Transcription Factor, APRF,Transcription Factor, STAT3,Transcription Factor, STAT3a,Transcription Factor, STAT3b,Transcription Factor, Stat3alpha,Transcription Factor, Stat3beta
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D018340	Receptors, Adrenergic, alpha-1	A subclass of alpha-adrenergic receptors that mediate contraction of SMOOTH MUSCLE in a variety of tissues such as ARTERIOLES; VEINS; and the UTERUS. They are usually found on postsynaptic membranes and signal through GQ-G11 G-PROTEINS.	Adrenergic alpha-1 Receptors,Receptors, alpha-1 Adrenergic,alpha-1 Adrenergic Receptors,Adrenergic Receptor, alpha-1,Adrenergic alpha-1A Receptors,Adrenergic alpha-1B Receptors,Adrenergic alpha-1D Receptors,Receptor, Adrenergic, alpha-1,Receptor, Adrenergic, alpha-1A,Receptor, Adrenergic, alpha-1B,Receptor, Adrenergic, alpha-1D,Receptors, Adrenergic, alpha-1A,Receptors, Adrenergic, alpha-1B,Receptors, Adrenergic, alpha-1D,alpha 1 Adrenergic Receptor,alpha-1A Adrenergic Receptor,alpha-1B Adrenergic Receptor,alpha-1C Adrenergic Receptor,alpha-1D Adrenergic Receptor,Adrenergic Receptor, alpha 1,Adrenergic Receptor, alpha-1A,Adrenergic Receptor, alpha-1B,Adrenergic Receptor, alpha-1C,Adrenergic Receptor, alpha-1D,Adrenergic Receptors, alpha-1,Adrenergic alpha 1 Receptors,Adrenergic alpha 1A Receptors,Adrenergic alpha 1B Receptors,Adrenergic alpha 1D Receptors,Receptor, alpha-1 Adrenergic,Receptor, alpha-1A Adrenergic,Receptor, alpha-1B Adrenergic,Receptor, alpha-1C Adrenergic,Receptor, alpha-1D Adrenergic,Receptors, Adrenergic alpha-1,Receptors, Adrenergic alpha-1A,Receptors, Adrenergic alpha-1B,Receptors, Adrenergic alpha-1D,Receptors, alpha 1 Adrenergic,alpha 1 Adrenergic Receptors,alpha 1A Adrenergic Receptor,alpha 1B Adrenergic Receptor,alpha 1C Adrenergic Receptor,alpha 1D Adrenergic Receptor,alpha-1 Adrenergic Receptor,alpha-1 Receptors, Adrenergic,alpha-1A Receptors, Adrenergic,alpha-1B Receptors, Adrenergic,alpha-1D Receptors, Adrenergic
D018341	Receptors, Adrenergic, alpha-2	A subclass of alpha-adrenergic receptors found on both presynaptic and postsynaptic membranes where they signal through Gi-Go G-PROTEINS. While postsynaptic alpha-2 receptors play a traditional role in mediating the effects of ADRENERGIC AGONISTS, the subset of alpha-2 receptors found on presynaptic membranes signal the feedback inhibition of NEUROTRANSMITTER release.	Adrenergic alpha-2 Receptors,Receptors, alpha-2 Adrenergic,alpha-2 Adrenergic Receptors,Adrenergic Receptor alpha(2C),Adrenergic Receptor alpha(2d),Adrenergic Receptor alpha-2C,Adrenergic Receptor alpha-2b,Adrenergic Receptor, alpha-2,Adrenergic alpha-2A Receptors,Adrenergic alpha-2B Receptors,Adrenergic alpha-2C Receptors,Adrenergic alpha-2D Receptors,Receptor, Adrenergic, alpha-2,Receptor, Adrenergic, alpha-2A,Receptor, Adrenergic, alpha-2B,Receptor, Adrenergic, alpha-2C,Receptor, Adrenergic, alpha-2D,Receptors, Adrenergic, alpha-2A,Receptors, Adrenergic, alpha-2B,Receptors, Adrenergic, alpha-2D,alpha 2 Adrenergic Receptors,alpha-2A Adrenergic Receptor,alpha-2B Adrenergic Receptor,alpha-2C Adrenergic Receptor,alpha-2D Adrenergic Receptor,Adrenergic Receptor alpha 2C,Adrenergic Receptor alpha 2b,Adrenergic Receptor, alpha 2,Adrenergic Receptor, alpha-2A,Adrenergic Receptor, alpha-2B,Adrenergic Receptor, alpha-2C,Adrenergic Receptor, alpha-2D,Adrenergic Receptors, alpha-2,Adrenergic alpha 2 Receptors,Adrenergic alpha 2A Receptors,Adrenergic alpha 2B Receptors,Adrenergic alpha 2C Receptors,Adrenergic alpha 2D Receptors,Receptor alpha-2C, Adrenergic,Receptor alpha-2b, Adrenergic,Receptor, alpha-2 Adrenergic,Receptor, alpha-2A Adrenergic,Receptor, alpha-2B Adrenergic,Receptor, alpha-2C Adrenergic,Receptor, alpha-2D Adrenergic,Receptors, Adrenergic alpha-2,Receptors, Adrenergic alpha-2A,Receptors, Adrenergic alpha-2B,Receptors, Adrenergic alpha-2C,Receptors, Adrenergic alpha-2D,Receptors, alpha 2 Adrenergic,alpha 2A Adrenergic Receptor,alpha 2B Adrenergic Receptor,alpha 2C Adrenergic Receptor,alpha 2D Adrenergic Receptor,alpha-2 Adrenergic Receptor,alpha-2 Receptors, Adrenergic,alpha-2A Receptors, Adrenergic,alpha-2B Receptors, Adrenergic,alpha-2C Receptors, Adrenergic,alpha-2C, Adrenergic Receptor,alpha-2D Receptors, Adrenergic,alpha-2b, Adrenergic Receptor
D020033	Protein Isoforms	Different forms of a protein that may be produced from different GENES, or from the same gene by ALTERNATIVE SPLICING.	Isoform,Isoforms,Protein Isoform,Protein Splice Variant,Splice Variants, Protein,Protein Splice Variants,Isoform, Protein,Isoforms, Protein,Splice Variant, Protein,Variant, Protein Splice,Variants, Protein Splice