Biomaterial Database

[Serum antibodies to Legionella pneumophila by indirect immunofluorescent antibody test in 269 hemodialysis patients and 353 healthy subjects]. 1991

T Morimoto

Department of Clinical Pathology, Juntendo University School of Medicine, Tokyo.

Serum antibodies to Legionella pneumophila serogroup I-VI were determined by indirect immunofluorescent antibody test in 269 hemodialysis patients and compared to 353 so called healthy subjects. Antigen suspension was prepared by incubation on B-CYE agar and adding formalin solution, then fixed on a micro slide glass, and reacted with serial serum dilutions. FITC-labeled goat antihuman immunoglobulin was added as a second antibody. 273 (77.3%) cases of control group had a titer of less than 1:4, 6 (1.7%) cases had a titer of 1: 32, and none had a titer of greater than or equal to 1: 64. There was no significant difference in sex and age. 173 (64.3%) hemodialysis patients had a titer of less than 1: 4, 13 (4.9%) cases had a titer of greater than or equal to 1: 64, and 5 (1.9%) cases had a titer of 1: 128, 42 (43.8%) of 96 cases who showed a titer of greater than or equal to 1: 4 had antibodies to Legionella pneumophila serogroup I. The titer in hemodialysis patients were higher than control group (p less than 0.005). The results of this study suspected that acute feverish disease and pneumonia of compromised host such as hemodialysis patients should be always thought of Legionnaires' infection.

UI	MeSH Term	Description	Entries
D007875	Legionella	Gram-negative aerobic rods, isolated from surface water or thermally polluted lakes or streams. Member are pathogenic for man. Legionella pneumophila is the causative agent for LEGIONNAIRES' DISEASE.
D007877	Legionnaires' Disease	An acute, sometimes fatal, pneumonia-like bacterial infection characterized by high fever, malaise, muscle aches, respiratory disorders and headache. It is named for an outbreak at the 1976 Philadelphia convention of the American Legion.	Legionella pneumophila Infections,Infections, Legionella pneumophila,Legionnaire Disease,Pontiac Fever,Disease, Legionnaire,Disease, Legionnaires',Fever, Pontiac,Infection, Legionella pneumophila,Legionella pneumophila Infection,Legionnaire's Disease,Legionnaires Disease
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009894	Opportunistic Infections	An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.	Infection, Opportunistic,Infections, Opportunistic,Opportunistic Infection
D005260	Female		Females
D005455	Fluorescent Antibody Technique	Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.	Antinuclear Antibody Test, Fluorescent,Coon's Technique,Fluorescent Antinuclear Antibody Test,Fluorescent Protein Tracing,Immunofluorescence Technique,Coon's Technic,Fluorescent Antibody Technic,Immunofluorescence,Immunofluorescence Technic,Antibody Technic, Fluorescent,Antibody Technics, Fluorescent,Antibody Technique, Fluorescent,Antibody Techniques, Fluorescent,Coon Technic,Coon Technique,Coons Technic,Coons Technique,Fluorescent Antibody Technics,Fluorescent Antibody Techniques,Fluorescent Protein Tracings,Immunofluorescence Technics,Immunofluorescence Techniques,Protein Tracing, Fluorescent,Protein Tracings, Fluorescent,Technic, Coon's,Technic, Fluorescent Antibody,Technic, Immunofluorescence,Technics, Fluorescent Antibody,Technics, Immunofluorescence,Technique, Coon's,Technique, Fluorescent Antibody,Technique, Immunofluorescence,Techniques, Fluorescent Antibody,Techniques, Immunofluorescence,Tracing, Fluorescent Protein,Tracings, Fluorescent Protein
D006435	Renal Dialysis	Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.	Dialysis, Extracorporeal,Dialysis, Renal,Extracorporeal Dialysis,Hemodialysis,Dialyses, Extracorporeal,Dialyses, Renal,Extracorporeal Dialyses,Hemodialyses,Renal Dialyses
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults