Biomaterial Database

Walking the AID tightrope. 2010

Mieun Lee-Theilen, and Jayanta Chaudhuri

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

UI	MeSH Term	Description	Entries
D003564	Cytidine Deaminase	An enzyme that catalyzes the deamination of cytidine, forming uridine. EC 3.5.4.5.	Cytidine Aminohydrolase,Aminohydrolase, Cytidine,Deaminase, Cytidine
D005786	Gene Expression Regulation	Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.	Gene Action Regulation,Regulation of Gene Expression,Expression Regulation, Gene,Regulation, Gene Action,Regulation, Gene Expression
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001402	B-Lymphocytes	Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.	B-Cells, Lymphocyte,B-Lymphocyte,Bursa-Dependent Lymphocytes,B Cells, Lymphocyte,B Lymphocyte,B Lymphocytes,B-Cell, Lymphocyte,Bursa Dependent Lymphocytes,Bursa-Dependent Lymphocyte,Lymphocyte B-Cell,Lymphocyte B-Cells,Lymphocyte, Bursa-Dependent,Lymphocytes, Bursa-Dependent
D014158	Transcription, Genetic	The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.	Genetic Transcription
D017578	Immunoglobulin Class Switching	Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing.	Class Switching,Ig Class Switching,Isotype Switching,Class Switching, Ig,Class Switching, Immunoglobulin,Class Switchings,Class Switchings, Ig,Class Switchings, Immunoglobulin,Ig Class Switchings,Immunoglobulin Class Switchings,Isotype Switchings,Switching, Class,Switching, Ig Class,Switching, Immunoglobulin Class,Switching, Isotype,Switchings, Class,Switchings, Ig Class,Switchings, Immunoglobulin Class,Switchings, Isotype
D027041	Somatic Hypermutation, Immunoglobulin	A programmed mutation process whereby changes are introduced to the nucleotide sequence of immunoglobulin gene DNA during development.	Hypermutation, Somatic, Immunoglobulin,Ig Somatic Hypermutation,Immunoglobulin Somatic Hypermutation,Somatic Hypermutation, Ig,Hypermutation, Ig Somatic,Hypermutation, Immunoglobulin Somatic,Hypermutations, Ig Somatic,Hypermutations, Immunoglobulin Somatic,Ig Somatic Hypermutations,Immunoglobulin Somatic Hypermutations,Somatic Hypermutations, Ig,Somatic Hypermutations, Immunoglobulin