OBJECTIVE To evaluate the safety and immunogenicity of the lyophilized live attenuated domestic varicella vaccine of Oka strain in Zhejiang province. METHODS 785 susceptible children aged 1-13 years, who had no history of VZV infection and had not been immunized, were observed. RESULTS The results showed that 2.29% children had adverse reactions after 30 mins of inoculation, 3.69% children had adverse reactions after 4 hours, 3.82% children had adverse reactions after 24 hours, 1.78% children had adverse reactions after 48 hours, 0.25% children had adverse reactions after 72 hours, no adverse reactions were observed after six weeks. There were 3.82% children had fever, The incidence rate of other adverse reactions such as swell and scleroma were low. The vaccine had high sero-converson rate. CONCLUSIONS The results showed that it has good safety and immunogenicity of the live attenuated domestic varicella vaccine.