Antibacterial surface properties of fluoride-containing resin-based sealants. 2010

Supawadee Naorungroj, and Hong-Hong Wei, and Roland R Arnold, and Edward J Swift, and Ricardo Walter
The University of North Carolina at Chapel Hill, School of Dentistry, Department of Operative Dentistry, Chapel Hill, NC 27599-7450, USA.

OBJECTIVE The aim of the present study was to determine the antibacterial properties of three resin-based pit and fissure sealant products: Clinpro (3M ESPE), Embrace (Pulpdent), and UltraSeal XT plus (Ultradent). METHODS The antibacterial effects of the sealants were tested in both an agar diffusion assay and a planktonic growth inhibition assay using Streptococcus mutans and Lactobacillus acidophilus. The materials were applied to paper and enamel disks in the former and on the side walls of 96-well microtiter plates on the latter. RESULTS All materials showed either diffusible or contact antibacterial effects in the agar diffusion assays. The effect was diminished when enamel disks were used as substrate. In the planktonic growth inhibition assay, Clinpro had its effect reduced, but retained activity against both bacteria over time. L. acidophilus was more sensitive than S. mutans to UltraSeal. Embrace retained antibacterial activity against both bacteria over time. CONCLUSIONS Within the limitations of this in vitro study it can be concluded that all materials are capable of contact inhibition of L. acidophilus and S. mutans growth. Embrace has the longer lasting antibacterial activity when in solution, especially against S. mutans.

UI MeSH Term Description Entries
D007779 Lactobacillus acidophilus A species of gram-positive, rod-shaped bacteria isolated from the intestinal tract of humans and animals, the human mouth, and vagina. This organism produces the fermented product, acidophilus milk. Lactobacillus amylovorus
D010895 Pit and Fissure Sealants Agents used to occlude dental enamel pits and fissures in the prevention of dental caries. Dental Sealant,Dental Sealants,Fissure Sealant,Fissure Sealants,Pit And Fissure Sealant,Pit Fissure Sealant,Sealants, Tooth,Pit Fissure Sealants,Sealants, Dental,Fissure Sealant, Pit,Fissure Sealants, Pit,Sealant, Dental,Sealant, Fissure,Sealant, Pit Fissure,Sealant, Tooth,Sealants, Fissure,Sealants, Pit Fissure,Tooth Sealant,Tooth Sealants
D005460 Fluorides, Topical Fluorides, usually in pastes or gels, used for topical application to reduce the incidence of DENTAL CARIES. Fluoride Varnishes,Topical Fluorides,Varnishes, Fluoride
D000900 Anti-Bacterial Agents Substances that inhibit the growth or reproduction of BACTERIA. Anti-Bacterial Agent,Anti-Bacterial Compound,Anti-Mycobacterial Agent,Antibacterial Agent,Antibiotics,Antimycobacterial Agent,Bacteriocidal Agent,Bacteriocide,Anti-Bacterial Compounds,Anti-Mycobacterial Agents,Antibacterial Agents,Antibiotic,Antimycobacterial Agents,Bacteriocidal Agents,Bacteriocides,Agent, Anti-Bacterial,Agent, Anti-Mycobacterial,Agent, Antibacterial,Agent, Antimycobacterial,Agent, Bacteriocidal,Agents, Anti-Bacterial,Agents, Anti-Mycobacterial,Agents, Antibacterial,Agents, Antimycobacterial,Agents, Bacteriocidal,Anti Bacterial Agent,Anti Bacterial Agents,Anti Bacterial Compound,Anti Bacterial Compounds,Anti Mycobacterial Agent,Anti Mycobacterial Agents,Compound, Anti-Bacterial,Compounds, Anti-Bacterial
D013295 Streptococcus mutans A polysaccharide-producing species of STREPTOCOCCUS isolated from human dental plaque.
D013499 Surface Properties Characteristics or attributes of the outer boundaries of objects, including molecules. Properties, Surface,Property, Surface,Surface Property
D052978 Disk Diffusion Antimicrobial Tests A method where a culturing surface inoculated with microbe is exposed to small disks containing known amounts of a chemical agent resulting in a zone of inhibition (usually in millimeters) of growth of the microbe corresponding to the susceptibility of the strain to the agent. Bauer-Kirby Disk-Diffusion Method,Epsilometer Test,Etest,Kirby-Bauer Disk-Diffusion Method,Bauer Kirby Disk Diffusion Method,Disk-Diffusion Method, Bauer-Kirby,Disk-Diffusion Method, Kirby-Bauer,Epsilometer Tests,Etests,Kirby Bauer Disk Diffusion Method,Test, Epsilometer,Tests, Epsilometer
D019279 Resin Cements Dental cements composed either of polymethyl methacrylate or dimethacrylate, produced by mixing an acrylic monomer liquid with acrylic polymers and mineral fillers. The cement is insoluble in water and is thus resistant to fluids in the mouth, but is also irritating to the dental pulp. It is used chiefly as a luting agent for fabricated and temporary restorations. (Jablonski's Dictionary of Dentistry, 1992, p159) Resin Cement,Cement, Resin,Cements, Resin

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