Immunoreactivity of endogenous digitalis-like factors. 1991

A Goto, and K Yamada, and M Ishii, and T Sugimoto, and M Yoshioka
Second Department of Internal Medicine, University of Tokyo, Japan.

Highly specific antisera produced against cardenolide (digoxin) and bufodienolide (bufalin) may bind the endogenous ouabain-displacing compounds from human urine. However, it should be borne in mind that the degree of recognition by the antisera significantly differ between two ouabain-displacing compounds.

UI MeSH Term Description Entries
D010042 Ouabain A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like DIGITALIS. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-EXCHANGING ATPASE. Acocantherin,G-Strophanthin,Acolongifloroside K,G Strophanthin
D001798 Blood Proteins Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins. Blood Protein,Plasma Protein,Plasma Proteins,Serum Protein,Serum Proteins,Protein, Blood,Protein, Plasma,Protein, Serum,Proteins, Blood,Proteins, Plasma,Proteins, Serum
D002018 Bufanolides Cyclopentanophenanthrenes with a 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. They are found in BUFONIDAE and often possess cardiotonic properties. Bufadienolides
D002298 Cardenolides C(23)-steroids with methyl groups at C-10 and C-13 and a five-membered lactone at C-17. They are aglycone constituents of CARDIAC GLYCOSIDES and must have at least one double bond in the molecule. The class includes cardadienolides and cardatrienolides. Members include DIGITOXIN and DIGOXIN and their derivatives and the STROPHANTHINS. Cardenolide
D003429 Cross Reactions Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen. Cross Reaction,Reaction, Cross,Reactions, Cross
D004077 Digoxin A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666) Digacin,Digitek,Digoregen,Digoxina Boehringer,Digoxine Nativelle,Dilanacin,Hemigoxine Nativelle,Lanacordin,Lanicor,Lanoxicaps,Lanoxin,Lanoxin-PG,Lenoxin,Mapluxin,Boehringer, Digoxina,Lanoxin PG,Nativelle, Digoxine,Nativelle, Hemigoxine
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000937 Antigen-Antibody Reactions The processes triggered by interactions of ANTIBODIES with their ANTIGENS. Antigen Antibody Reactions,Antigen-Antibody Reaction,Reaction, Antigen-Antibody,Reactions, Antigen-Antibody
D001667 Binding, Competitive The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements. Competitive Binding
D012503 Saponins A type of glycoside widely distributed in plants. Each consists of a sapogenin as the aglycone moiety, and a sugar. The sapogenin may be a steroid or a triterpene and the sugar may be glucose, galactose, a pentose, or a methylpentose. Saponin

Related Publications

A Goto, and K Yamada, and M Ishii, and T Sugimoto, and M Yoshioka
January 1993, Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques,
A Goto, and K Yamada, and M Ishii, and T Sugimoto, and M Yoshioka
January 1992, Clinical and experimental hypertension. Part A, Theory and practice,
A Goto, and K Yamada, and M Ishii, and T Sugimoto, and M Yoshioka
June 1991, Trends in pharmacological sciences,
A Goto, and K Yamada, and M Ishii, and T Sugimoto, and M Yoshioka
January 1986, Critical reviews in clinical laboratory sciences,
A Goto, and K Yamada, and M Ishii, and T Sugimoto, and M Yoshioka
January 1987, Annual review of medicine,
A Goto, and K Yamada, and M Ishii, and T Sugimoto, and M Yoshioka
March 1987, The New England journal of medicine,
A Goto, and K Yamada, and M Ishii, and T Sugimoto, and M Yoshioka
August 1987, The New England journal of medicine,
A Goto, and K Yamada, and M Ishii, and T Sugimoto, and M Yoshioka
July 1988, Casopis lekaru ceskych,
A Goto, and K Yamada, and M Ishii, and T Sugimoto, and M Yoshioka
September 1985, Federation proceedings,
A Goto, and K Yamada, and M Ishii, and T Sugimoto, and M Yoshioka
July 1986, The American journal of physiology,
Copied contents to your clipboard!