Antinociceptive profiles and mechanisms of orally administered vanillin in the mice. 2009

Soo-Hyun Park, and Yun-Beom Sim, and Seung-Min Choi, and Young-Jun Seo, and Min-Soo Kwon, and Jin-Koo Lee, and Hong-Won Suh
Department of Pharmacology, Institute of Natural Medicine, College of Medicine, Hallym University, Chuncheon 200-702, Korea.

In the present study, the antinociceptive profiles of vanillin were examined in ICR mice. Vanillin administered orally (from 1 to 10 mg/kg) showed an antinociceptive effect in a dose-dependent manner as measured in the acetic acid-induced writhing test. Duration of antinociceptive action of vanillin maintained at least for 30 min. But, the cumulative response time of nociceptive behaviors induced by a subcutaneous (s.c.) formalin injection, intrathecal (i.t.) substance P (0.7 microg) or glutamate (20 microg) injection was not affected by vanillin. Intraperitoneal (i.p.) pretreatment with yohimbine (alpha2-adrenergic receptor antagonist) or naloxone (opioid receptor antagonist) attenuated antinociceptive effect induced by vanillin in the writhing test. However, phentolamine (alpha1-adrenergic receptor antagonist) or methysergide (5-HT serotonergic receptor antagonist) did not affect antinociception induced by vanillin in the writhing test. Our results suggest that vanillin exerts a selective antinociceptive property in the acetic acid-induced visceral inflammatory pain model. Furthermore, this antinociceptive effect of vanillin may be mediated by alpha2-adrenergic and opioid receptors, but not alpha1-adrenergic and serotonergic receptors.

UI MeSH Term Description Entries
D007249 Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function. Innate Inflammatory Response,Inflammations,Inflammatory Response, Innate,Innate Inflammatory Responses
D008297 Male Males
D008813 Mice, Inbred ICR An inbred strain of mouse that is used as a general purpose research strain, for therapeutic drug testing, and for the genetic analysis of CARCINOGEN-induced COLON CANCER. Mice, Inbred ICRC,Mice, ICR,Mouse, ICR,Mouse, Inbred ICR,Mouse, Inbred ICRC,ICR Mice,ICR Mice, Inbred,ICR Mouse,ICR Mouse, Inbred,ICRC Mice, Inbred,ICRC Mouse, Inbred,Inbred ICR Mice,Inbred ICR Mouse,Inbred ICRC Mice,Inbred ICRC Mouse
D010146 Pain An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS. Suffering, Physical,Ache,Pain, Burning,Pain, Crushing,Pain, Migratory,Pain, Radiating,Pain, Splitting,Aches,Burning Pain,Burning Pains,Crushing Pain,Crushing Pains,Migratory Pain,Migratory Pains,Pains, Burning,Pains, Crushing,Pains, Migratory,Pains, Radiating,Pains, Splitting,Physical Suffering,Physical Sufferings,Radiating Pain,Radiating Pains,Splitting Pain,Splitting Pains,Sufferings, Physical
D011957 Receptors, Opioid Cell membrane proteins that bind opioids and trigger intracellular changes which influence the behavior of cells. The endogenous ligands for opioid receptors in mammals include three families of peptides, the enkephalins, endorphins, and dynorphins. The receptor classes include mu, delta, and kappa receptors. Sigma receptors bind several psychoactive substances, including certain opioids, but their endogenous ligands are not known. Endorphin Receptors,Enkephalin Receptors,Narcotic Receptors,Opioid Receptors,Receptors, Endorphin,Receptors, Enkephalin,Receptors, Narcotic,Receptors, Opiate,Endorphin Receptor,Enkephalin Receptor,Normorphine Receptors,Opiate Receptor,Opiate Receptors,Opioid Receptor,Receptors, Normorphine,Receptors, beta-Endorphin,beta-Endorphin Receptor,Receptor, Endorphin,Receptor, Enkephalin,Receptor, Opiate,Receptor, Opioid,Receptor, beta-Endorphin,Receptors, beta Endorphin,beta Endorphin Receptor,beta-Endorphin Receptors
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D000284 Administration, Oral The giving of drugs, chemicals, or other substances by mouth. Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D000700 Analgesics Compounds capable of relieving pain without the loss of CONSCIOUSNESS. Analgesic,Anodynes,Antinociceptive Agents,Analgesic Agents,Analgesic Drugs,Agents, Analgesic,Agents, Antinociceptive,Drugs, Analgesic
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

Soo-Hyun Park, and Yun-Beom Sim, and Seung-Min Choi, and Young-Jun Seo, and Min-Soo Kwon, and Jin-Koo Lee, and Hong-Won Suh
June 2003, Life sciences,
Soo-Hyun Park, and Yun-Beom Sim, and Seung-Min Choi, and Young-Jun Seo, and Min-Soo Kwon, and Jin-Koo Lee, and Hong-Won Suh
January 2003, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
Soo-Hyun Park, and Yun-Beom Sim, and Seung-Min Choi, and Young-Jun Seo, and Min-Soo Kwon, and Jin-Koo Lee, and Hong-Won Suh
August 2021, Naunyn-Schmiedeberg's archives of pharmacology,
Soo-Hyun Park, and Yun-Beom Sim, and Seung-Min Choi, and Young-Jun Seo, and Min-Soo Kwon, and Jin-Koo Lee, and Hong-Won Suh
July 2000, Journal of ethnopharmacology,
Soo-Hyun Park, and Yun-Beom Sim, and Seung-Min Choi, and Young-Jun Seo, and Min-Soo Kwon, and Jin-Koo Lee, and Hong-Won Suh
April 2018, Neuropeptides,
Soo-Hyun Park, and Yun-Beom Sim, and Seung-Min Choi, and Young-Jun Seo, and Min-Soo Kwon, and Jin-Koo Lee, and Hong-Won Suh
September 2010, American journal of veterinary research,
Soo-Hyun Park, and Yun-Beom Sim, and Seung-Min Choi, and Young-Jun Seo, and Min-Soo Kwon, and Jin-Koo Lee, and Hong-Won Suh
September 2002, Planta medica,
Soo-Hyun Park, and Yun-Beom Sim, and Seung-Min Choi, and Young-Jun Seo, and Min-Soo Kwon, and Jin-Koo Lee, and Hong-Won Suh
June 1980, Toxicology and applied pharmacology,
Soo-Hyun Park, and Yun-Beom Sim, and Seung-Min Choi, and Young-Jun Seo, and Min-Soo Kwon, and Jin-Koo Lee, and Hong-Won Suh
January 1993, Drug metabolism and disposition: the biological fate of chemicals,
Soo-Hyun Park, and Yun-Beom Sim, and Seung-Min Choi, and Young-Jun Seo, and Min-Soo Kwon, and Jin-Koo Lee, and Hong-Won Suh
October 1996, General pharmacology,
Copied contents to your clipboard!