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Secondary structure prediction parameters and optimised decision constants for use with the method of Garnier et al. [(1978) J. Mol. Biol. 120, 97-120] have been derived for two new and distinct substates of beta-structure. These we term internal and external on the basis of their hydrogen bonding patterns. The profiles of the amino acids for several of the parameters are considerably different in the two substates. Predictions using the new parameters attempt to distinguish the strands at the core of the beta-sheet from those at its edges and so restrict the possible topologies in tertiary structure prediction. The potential application of these parameters is illustrated for the class of beta/alpha proteins.
R C Garratt, and
J M Thornton, and
W R Taylor
July 2003,
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R C Garratt, and
J M Thornton, and
W R Taylor
March 1976,
Biophysical chemistry,
R C Garratt, and
J M Thornton, and
W R Taylor
October 2003,
Proceedings of the National Academy of Sciences of the United States of America,
R C Garratt, and
J M Thornton, and
W R Taylor
February 1987,
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R C Garratt, and
J M Thornton, and
W R Taylor
January 1996,
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R C Garratt, and
J M Thornton, and
W R Taylor
February 2012,
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R C Garratt, and
J M Thornton, and
W R Taylor
July 2011,
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R C Garratt, and
J M Thornton, and
W R Taylor
July 2010,
RNA (New York, N.Y.),
R C Garratt, and
J M Thornton, and
W R Taylor
February 2008,
Bioinformatics (Oxford, England),
R C Garratt, and
J M Thornton, and
W R Taylor
May 2001,
Current protocols in protein science,
