Understanding the time variant connectivity of the language network in developmental dyslexia: new insights using Granger causality. 2010

Carolin Ligges, and M Ungureanu, and M Ligges, and B Blanz, and H Witte
Department of Child and Adolescent Psychiatry, Friedrich Schiller University, Philosophenweg 3-5, 07743 Jena, Germany. Carolin.Ligges@med.uni-jena.de

The reading process takes place in a neuronal network comprising the inferior frontal, posterior dorsal and posterior ventral brain areas. It is suggested that developmental dyslexia is caused by a disruption of the two posterior network areas. What remains debatable is whether these areas are affected in their functionality or whether the neuronal networking (connectivity) of these areas suffer from a disturbed information transfer. Thus, it is of major interest to investigate the time flow of the directed information transfer (time variant connectivity) within the neuronal reading network of dyslexic subjects. We investigated adolescents with dyslexia and normal-reading controls with functional magnetic resonance imaging and electroencephalography (EEG) with a paradigm addressing basic visual, orthographic and phonological processing. EEG data were analyzed with the time variant Granger causality index (tvGCI) to investigate the temporal order of the directed information transfer (time variant causal connectivity: which network node passes when information to which network node) during reading in dyslexic readers. Results show that the reading network of dyslexic readers comprises the same brain areas as identified in normal-reading subjects. The tvGCI analysis of the network profiles of dyslexic readers indicates that dyslexics show a difference in timing and localization of connectivity within this reading network compared to normal readers. Dyslexic readers use right hemisphere language areas to counterbalance posterior left hemisphere processing deficits. The compensatory involvement of homologue right hemisphere brain areas for the reading process may be the neurobiological background for the significantly longer reading times by dyslexics.

UI MeSH Term Description Entries
D007802 Language A verbal or nonverbal means of communicating ideas or feelings. Dialect,Dialects,Languages
D007839 Functional Laterality Behavioral manifestations of cerebral dominance in which there is preferential use and superior functioning of either the left or the right side, as in the preferred use of the right hand or right foot. Ambidexterity,Behavioral Laterality,Handedness,Laterality of Motor Control,Mirror Writing,Laterality, Behavioral,Laterality, Functional,Mirror Writings,Motor Control Laterality,Writing, Mirror,Writings, Mirror
D008279 Magnetic Resonance Imaging Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques. Chemical Shift Imaging,MR Tomography,MRI Scans,MRI, Functional,Magnetic Resonance Image,Magnetic Resonance Imaging, Functional,Magnetization Transfer Contrast Imaging,NMR Imaging,NMR Tomography,Tomography, NMR,Tomography, Proton Spin,fMRI,Functional Magnetic Resonance Imaging,Imaging, Chemical Shift,Proton Spin Tomography,Spin Echo Imaging,Steady-State Free Precession MRI,Tomography, MR,Zeugmatography,Chemical Shift Imagings,Echo Imaging, Spin,Echo Imagings, Spin,Functional MRI,Functional MRIs,Image, Magnetic Resonance,Imaging, Magnetic Resonance,Imaging, NMR,Imaging, Spin Echo,Imagings, Chemical Shift,Imagings, Spin Echo,MRI Scan,MRIs, Functional,Magnetic Resonance Images,Resonance Image, Magnetic,Scan, MRI,Scans, MRI,Shift Imaging, Chemical,Shift Imagings, Chemical,Spin Echo Imagings,Steady State Free Precession MRI
D008297 Male Males
D009434 Neural Pathways Neural tracts connecting one part of the nervous system with another. Neural Interconnections,Interconnection, Neural,Interconnections, Neural,Neural Interconnection,Neural Pathway,Pathway, Neural,Pathways, Neural
D011932 Reading Acquiring information from text.
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D001931 Brain Mapping Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures. Brain Electrical Activity Mapping,Functional Cerebral Localization,Topographic Brain Mapping,Brain Mapping, Topographic,Functional Cerebral Localizations,Mapping, Brain,Mapping, Topographic Brain
D004410 Dyslexia A cognitive disorder characterized by an impaired ability to comprehend written and printed words or phrases despite intact vision. This condition may be developmental or acquired. Developmental dyslexia is marked by reading achievement that falls substantially below that expected given the individual's chronological age, measured intelligence, and age-appropriate education. The disturbance in reading significantly interferes with academic achievement or with activities of daily living that require reading skills. (From DSM-IV) Alexia,Dyslexia, Developmental,Reading Disability, Developmental,Reading Disorder,Reading Disorder, Developmental,Developmental Reading Disorder,Word Blindness,Alexias,Blindness, Word,Blindnesses, Word,Developmental Dyslexia,Developmental Dyslexias,Developmental Reading Disabilities,Developmental Reading Disability,Developmental Reading Disorders,Disabilities, Developmental Reading,Disability, Developmental Reading,Disorder, Developmental Reading,Disorder, Reading,Disorders, Developmental Reading,Disorders, Reading,Dyslexias,Dyslexias, Developmental,Reading Disabilities, Developmental,Reading Disorders,Reading Disorders, Developmental,Word Blindnesses
D004569 Electroencephalography Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain. EEG,Electroencephalogram,Electroencephalograms

Related Publications

Carolin Ligges, and M Ungureanu, and M Ligges, and B Blanz, and H Witte
January 2009, Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference,
Carolin Ligges, and M Ungureanu, and M Ligges, and B Blanz, and H Witte
September 2016, Physical review. E,
Carolin Ligges, and M Ungureanu, and M Ligges, and B Blanz, and H Witte
May 2011, Neural systems & circuits,
Carolin Ligges, and M Ungureanu, and M Ligges, and B Blanz, and H Witte
March 2017, Brain connectivity,
Carolin Ligges, and M Ungureanu, and M Ligges, and B Blanz, and H Witte
October 2013, IET systems biology,
Carolin Ligges, and M Ungureanu, and M Ligges, and B Blanz, and H Witte
October 2018, Language, speech, and hearing services in schools,
Carolin Ligges, and M Ungureanu, and M Ligges, and B Blanz, and H Witte
January 2016, Frontiers in neuroinformatics,
Carolin Ligges, and M Ungureanu, and M Ligges, and B Blanz, and H Witte
March 2019, Genes,
Carolin Ligges, and M Ungureanu, and M Ligges, and B Blanz, and H Witte
February 2019, Human brain mapping,
Carolin Ligges, and M Ungureanu, and M Ligges, and B Blanz, and H Witte
January 2010, Biological cybernetics,
Copied contents to your clipboard!